ELEVATED MEAN PLATELET VOLUME IS ASSOCIATED WITH GESTATIONAL DIABETES MELLITUS

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 806-823-Gestational Diabetes
Basic/Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-812
Ozlem Turhan Iyidir, Ceyla Konca Degertekin*, Fusun Toruner, Mujde Akturk and Metin Arslan
Gazi University Faculty of Medicine, Ankara, Turkey
Background: The mean platelet volume (MPV) is an indicator of the average size and activity of platelets. Elevated MPV values are associated with larger and more active platelets and perceived as a new independent cardiovascular risk factor. Several studies showed that MPV is increased in the presence of diabetes mellitus and metabolic syndrome. The aim of this study was to determine the MPV in women with gestational diabetes compared to women with healthy pregnancies and to determine the correlation of MPV with metabolic parameters in gestational diabetic women.

Method: We analyzed 30 pregnant women with gestational diabetes and 38 body mass index (BMI)-matched women with healthy pregnancies as controls. MPV and platelet counts were recorded in the 3rd trimester in both groups and at postpartum 6-12. months in the gestational diabetes group. Fasting plasma glucose and fetal birth weight data were obtained and oral glucose tolerance test glucose area under the curve (AUC)  was calculated.

Results: Third trimester MPV was significantly higher in the gestational diabetes group than the control group (8.8±1.0 vs 8.1±0.7 fl, p=0.002). In women with gestational diabetes, there was a significant decrease in MPV in the postpartum period (8.8±1.0 vs 8.1±0.8 fl, p<0.001). Fasting plasma glucose levels (r=0.346, p=0.007) and glucose AUC (r=0.346, p=0.02) were positively correlated with the 3rd trimester MPV. In gestational diabetes group, MPV was not correlated with pre-pregnancy BMI (p=0.119) or fetal birth weight (p=0.304).

Conclusion: Our results indicate that MPV is increased in gestational diabetes and is associated with hyperglycemia. Further research is warranted in this area.

Nothing to Disclose: OT, CK, FT, MA, MA

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