Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 471-496-Thyroid Neoplasia & Case Reports
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-487
Nanik Ram* and Najmul Islam
Aga Khan University Hospital, Karachi, Pakistan

Palpable thyroid nodules occur in about 5% of the population. Approximately 5–9% of thyroid nodules are malignant. A thyroid ultrasound scan is recommended in the assessment of any suspected thyroid nodule. The ultrasound characteristics of nodules have been shown to be useful in assessing their malignant potential. The aim of this study is to determine diagnostic validity of thyroid ultrasound in differentiating benign & malignant thyroid nodule.

Material and Methods

It was cross sectional study, conducted at Aga Khan University Hospital Karachi from August 2011- July 2012. All patients of either gender with thyroid nodules referred for ultrasound thyroid and FNAC were included. Patients with known thyroid malignancy, pure cystic lesion, indeterminate, non-diagnostic, suspicious finding in cytology without subsequent surgery were excluded. Ultrasonography was performed by radiologists with Toshiba US machines. The ultrasound parameters were assessed and compared with FNAC results in all nodules. Diagnostic validity of each ultrasound feature was calculated. Study was approved from Ethical Review Committee of Hospital.


Total 101 patients were included in the study on this basis of availability of ultrasound images, pathology report and after exclusion. Mean age of patients was 43 ±13 Years (Range 15-73 Years) and n=81(80%) were females. Among 101, n=96 benign and n=5 nodules were malignant on histocytopathology. The sensitivity & specificity of each ultrasound feature in predicting malignancy were: microcalcification, 80% 68%; hypoechogenicity, 80% 52%; ill defined lobulated margin, 40% 96%; solid, 80% 40%; taller than wider, 50% 63% respectively. Each US feature have negative predictive value ranges from 95-98%.


Identification of microcalcification, hypoechogenicity & solid with ill defined margins thyroid nodules on ultrasound is helpful in diagnosing thyroid malignancy and warrants urgent diagnostic biopsy.

Nothing to Disclose: NR, NI

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm