Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Poster Board SUN-267
Objective: To examine the relationship between serum 25(OH)D levels and certain adipokines specifically related to type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in obese adolescents.
Study Design: In 46 (12-18 yr old) obese Caucasian adolescents (BMI at or greater than > 95th percentile for age and gender) serum 25(OH)D (liquid chromatography-tandem mass spectrometry), total (T) adiponectin, high molecular weight (HMW) adiponectin, interleukin 6 (IL-6) and retinol binding protein 4 (RBP4) were measured (all ELISA). Spearman correlations were performed to determine potential correlations between 25(OH)D levels and the adipokines.
Results: The mean serum 25(OH)D was 24 ng/mL. 25(OH)D levels were < 30 ng/mL( considered by many expert groups as the cut off level for vitamin D sufficiency) for 83% of the cohort studied. Despite the obesity-related alterations reported for vitamin D status and adipokines such as adiponectin (both T and HMW), IL-6 and RBP4, there was no correlation between serum 25(OH)D and these adipokines..
Conclusions: Although 25(OH)D deficiency and alterations in adipokines (closely related to T2DM and CVD) have been reported in adults, the current study in an obese cohort of Caucasian adolescents suggests lack of such associations between vitamin D deficiency and obesity-related alterations in adipokines. Future controlled studies in larger cohorts are warranted considering the high prevalence of vitamin D deficiency/insufficiency and alterations in risk factors of T2DM and CVD in obese children.
Nothing to Disclose: AJ, PPB, AV, PF, AW, PG, JL, SK
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