Relationship between 25-Hydroxyvitamin D status and Adipokines in Obese Caucasian Adolescents

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Basic/Translational
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-267
Asma Javed*1, Prabhakara P Balagopal2, Adrian Vella1, Philip Fischer1, Amy Weaver1, Paula Giesler1, Jeanette Laugen1 and Seema Kumar1
1Mayo Clinic, Rochester, MN, 2Res Div, Jacksonville, FL
Background:  Vitamin D deficiency is extremely common in obese adolescents. The extraskeletal health implications of vitamin D deficiency in obese children and adolescents are not well understood.  Although serum 25 hydroxy-vitamin D [25(OH)D] deficiency is associated with obesity-related alterations in various adipokines in adults, such a relationship in children is less clear. 

Objective: To examine the relationship between serum 25(OH)D levels and certain adipokines specifically related to type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in obese adolescents.

Study Design: In 46 (12-18 yr old) obese Caucasian adolescents (BMI at or greater than > 95th percentile for age and gender) serum 25(OH)D (liquid chromatography-tandem mass spectrometry), total (T) adiponectin, high molecular weight (HMW) adiponectin, interleukin 6 (IL-6) and retinol binding protein 4 (RBP4) were measured (all ELISA). Spearman correlations were performed to determine potential correlations between 25(OH)D levels and the adipokines.  

Results: The mean serum 25(OH)D was 24 ng/mL. 25(OH)D levels were  < 30 ng/mL( considered by many expert groups as the cut off level for vitamin D sufficiency) for 83% of the cohort studied. Despite the obesity-related alterations reported for vitamin D status and adipokines such as adiponectin (both T and HMW), IL-6 and RBP4, there was no correlation between serum 25(OH)D and these adipokines..    

Conclusions: Although 25(OH)D deficiency and alterations in adipokines (closely related to T2DM and CVD) have been reported in adults, the current study in an obese cohort of Caucasian adolescents suggests lack of such associations between vitamin D deficiency and obesity-related alterations in adipokines. Future controlled studies in larger cohorts are warranted considering the high prevalence of vitamin D deficiency/insufficiency and alterations in risk factors of T2DM and CVD in obese children.

Nothing to Disclose: AJ, PPB, AV, PF, AW, PG, JL, SK

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm