SHORT TERM STATIN TREATMENT DECREASES DOMINANT THYRIOID NODULE VOLUME

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 437-470-Non-neoplastic Thyroid Disorders
Basic/Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-464
Nese Ersoz Gulcelik*1, Kadriye Aydin2, Cafer Balci3, Murat Tuncel3, Safak Akin3, Nese Cinar4, Firuzan Firat3, Meltem Caglar3, Aydan Usman5 and Alper Gurlek6
1Ankara Numune Training and Research Hospital, Ankara, Turkey, 2Hacettepe University, Ankara, Turkey, 3Hacettepe Medical School, 4Hacettepe University Medical School, Ankara, Turkey, 5Hacettepe Medical school, 6Hacettepe University School of Medicine, Ankara, Turkey
SHORT TERM STATIN TREATMENT DECREASES DOMINANT THYRIOID NODULE VOLUME

Background: The antigoitrogenic effect of statins is of clinical interest. Long term statin use was shown to be associated with decrease in thyroid volume and nodul volume and numbers. Increased VEGF expression and its receptors in nodular tissue of uninodular and recurrent goiter as well as in the entire tissue of multinodular was demonstrated. We hypothesized that VEGF may be involved in the antigoitrogenic effect of statin treatment.

Design and Methods: Seventy patients intended to start statin treatment according to ATP-III criteria were included in the study. Patients were evaluated before treatment and after six months of statin treatment. Anthropometric measurements, thyroid volume, number of thyroid nodules, thyroid nodule volumes and dominant nodule volume were recorded. Lipid parameters, glucose metabolism parameters including homeostasis model assessment of insulin resistance (HOMA-IR) and vascular endothelial growth factor (VEGF) levels were analyzed and correlated with the parameters of thyroid volumes before and after treatment

Results: Statin therapy resulted in a decrease in dominant nodule volume [0.16 ml (range0.01-6.09) to 0.14 ml (0.01-6.44), p=0.013]. Serum VEGF levels were decreased after six months’ statin treatment (535.9± 257.9pg/ml vs.516.9±252.6pg/ml, p<0,001). Serum VEGF levels were not correlated with thyroid volume measurements both before and after statin treatment.       

Conclusions: Long term statin treatment was shown to result in a decrease in thyroid volume and nodules. In our study, we demonstrated that  realtively short term statin treatment has an effect on  lowering the volume of dominant nodule. Altough there was a decrease in serum VEGF levels by statin treatment there was no correlation between serum VEGF levels and thyroid nodule volumes.

Nothing to Disclose: NE, KA, CB, MT, SA, NC, FF, MC, AU, AG

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