Session: MON 437-470-Non-neoplastic Thyroid Disorders
Poster Board MON-464
Background: The antigoitrogenic effect of statins is of clinical interest. Long term statin use was shown to be associated with decrease in thyroid volume and nodul volume and numbers. Increased VEGF expression and its receptors in nodular tissue of uninodular and recurrent goiter as well as in the entire tissue of multinodular was demonstrated. We hypothesized that VEGF may be involved in the antigoitrogenic effect of statin treatment.
Design and Methods: Seventy patients intended to start statin treatment according to ATP-III criteria were included in the study. Patients were evaluated before treatment and after six months of statin treatment. Anthropometric measurements, thyroid volume, number of thyroid nodules, thyroid nodule volumes and dominant nodule volume were recorded. Lipid parameters, glucose metabolism parameters including homeostasis model assessment of insulin resistance (HOMA-IR) and vascular endothelial growth factor (VEGF) levels were analyzed and correlated with the parameters of thyroid volumes before and after treatment
Results: Statin therapy resulted in a decrease in dominant nodule volume [0.16 ml (range0.01-6.09) to 0.14 ml (0.01-6.44), p=0.013]. Serum VEGF levels were decreased after six months’ statin treatment (535.9± 257.9pg/ml vs.516.9±252.6pg/ml, p<0,001). Serum VEGF levels were not correlated with thyroid volume measurements both before and after statin treatment.
Conclusions: Long term statin treatment was shown to result in a decrease in thyroid volume and nodules. In our study, we demonstrated that realtively short term statin treatment has an effect on lowering the volume of dominant nodule. Altough there was a decrease in serum VEGF levels by statin treatment there was no correlation between serum VEGF levels and thyroid nodule volumes.
Nothing to Disclose: NE, KA, CB, MT, SA, NC, FF, MC, AU, AG
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