Session: OR47-Hypothalamus-Pituitary Development & Biology
Room 130 (Moscone Center)
Senktide induced a significant increase in LH and FSH release in pre-pubertal rats; FSH responses to Kp-10 were also detected at this age. In contrast, senktide failed to induce FSH release in adult female rats, either intact (at diestrus) or ovariectomized followed by sham or estradiol replacement, despite its ability to stimulate LH release. In turn, adult males, which were highly responsive to Kp-10, did not display FSH or LH responses to senktide. In addition, pre-treatment of adult rats with the KOR antagonist, nor-BNI, increased basal LH and FSH levels and permitted senktide-induced LH (but not FSH) release in males, as well as clear FSH responses in females.
In sum, in this work, we have documented (a) the divergent patterns of gonadotropin (FSH vs. LH) responses to NKB and Kp-10 stimulation; and (b) the role of Dyn signaling in inhibiting basal gonadotropin secretion and their responses to NKB. Our data contribute to refine our present understanding on how different elements of the KNDy node participate in the dynamic and differential control of the secretion of both gonadotropins in both sexes and at different stages of postnatal maturation.
Nothing to Disclose: FR, DG, MM, SL, MAS, JR, LP, VMN, MT
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