Changes in The Cardiovascular Risk Factors and İnsulin Resistance after Curative Parathyroidectomy in Patients with Parathyroid Adenoma

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 234-256-Bone & Calcium Metabolism: Clinical Trials & Case Series
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-245
Mustafa Caliskan*1, Basak Karbek2, Melia Karaköse1, İlknur Ozturk Unsal1, Erman Cakal3, Bekir Ucan3 and Tuncay Delibasi4
1Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey, 2Diskapi Yildirim Beyazit, Ankara, Turkey, 3Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, 4Diskapi Yildirim Beyazıd Training and Research Hospital, Ankara, Turkey
Introduction: Metabolic abnormalities such as impaired glucose tolerance or diabetes mellitus and  lipid profile changes are frequently detected in patients with primary hyperparathyroidism (PHPT).  Previous studies have shown the association of PHPT with cardiovascular morbidity and mortality.  In this study, we aimed to present a case series including 17 patients who had parathyroidectomy after the diagnosis of parathyroid adenoma.  Materials and Methods: In this study we included patients who admitted to Dışkapı Yıldırım Beyazıt Training & Research Hospital, Divison of Endocrinology and Metabolism between January 2011-December 2012 and who had parathyroidectomy  as  a result of primary hyperparathyroidism.  Before the operation and after  6 months of operation ;   serum lipid profile, fasting insulin levels were measured and insulin resistance calculated by  HOMA-IR, carotid intima-media thickness (CIMT) of all patients were evaluated by high resolution B-mode ultrasonography.  Results: All patients after parathyroidectomy had normal serum calcium, phosphorus and PTH levels. Metabolic values are given before and after operation in the table 1. Preoperative HOMA-IR and CIMT  values were compared with postoperative values  and  we  detected that  statistically significant decrease in postoparative situation (HOMA-IR; preoperative: 3.67±2.43  postoperative: 2.22±1.05 p=0.002,   CIMT; preoperative: 3.67±2.43  postoperative: 2.22±1.05  p=0.002 ). There were not a statistically significant correlation between calcium, phosphorus, PTH, vitamin D levels and HOMA-IR, CIMT values. Conclutions: This study confirms an impairment of insulin sensitivity and CIMT in primer hyperparathyroid patients when compared with pre and post operative conditions. In PHPT, parathyroidectomy led to significant changes in some cardiovascular indices. Improvements were mainly evident in those with pre-existing cardiovascular abnormalities particularly elevated CIMT and HOMA-IR.

Nothing to Disclose: MC, BK, MK, O, EC, BU, TD

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm