SIGNIFICANT REDUCTION IN THE SIZE OF CYSTIC THYROID NODULES WITH 131IODINE THERAPY

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 437-470-Non-neoplastic Thyroid Disorders
Basic/Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-467
April Melody de la Torre Abcede*, Sjoberg Ang Kho, Bien J. Matawaran and Leilani Basa Mercado-Asis
University of Santo Tomas Hospital, Manila City, Philippines
SIGNIFICANT REDUCTION IN THE SIZE OF CYSTIC THYROID NODULES WITH 131IODINE THERAPY April Melody T. Abcede, MD*; Sjoberg A. Kho, MD**; Bien J. Matawaran, MD**; Leilani B. Mercado-Asis, MD, PhD MPH** *Fellow, Section of Endocrinology and Metabolism, University of Santo Tomas Hospital, Manila, Philippines **Consultant, Section of Endocrinology and Metabolism, University of Santo Tomas Hospital, Manila, Philippines. Email: lanibmasis@gmail.com Background: Cystic nodules are non-responsive to suppression therapy and its rapid re-accumulation and increase in size is related to high levels of VEGF/VPF concentration that may need repeated aspiration or even surgical resection. 131Iodine therapy has not been utilized as one of the treatment options. Its net effect of local tissue damage with consequent thyroid fibrosis may ligate the vasculature supplying the cystic lesion leading to its resolution. Objective: This study aims to demonstrate the successful volume reduction of pure and predominantly cystic thyroid nodule using 131Iodine therapy. Methodology: A descriptive chart review of seven patients diagnosed with solitary cystic thyroid nodules was done. All nodules were confirmed benign with histopathologic studies. 131Iodine therapy was given at 10 to 20 mCi. Six patients underwent single therapy while one patient had more than two treatments. Ultrasonographic measurements of thyroid nodules and TSH levels were determined at baseline and compared with values at 3 to 6 months after therapy. Results: There was female predominance (83%) with mean age of 35 years. Five had purely cystic nodules while two had complex nodules predominantly cystic. There was 43% reduction in thyroid cyst size from a mean volume of 2.47cc at baseline to a mean of 1.41cc on last follow-up. There was a 33% decrease in thyroid lobe size in all subjects. In one patient with two years history of recurrent cystic nodular goiter, aspirated volume decreased from 12 mL to 9 mL on the 3rd 131Iodine therapy. A dry tap was obtained four months post therapy. Mean levothyroxine replacement dose was at 68 mcg post therapy to maintain a TSH level of <2uIU/ml. No untoward events were noted in all patients. Conclusion: 131Iodine therapy is effective in volume reduction of pure cystic and predominantly cystic thyroid nodules and is a better and safe nonsurgical alternative treatment.

Nothing to Disclose: AMDLTA, SAK, BJM, LBM

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