Session: SUN 338-365-Metabolic & Stress Receptors in Energy Homeostasis
Poster Board SUN-363
The growing wealth of sequenced genomes and comparative genomic approaches provide us with opportunities to successfully explore non-vertebrate models to elucidate the genetic elements of endocrine diseases. Here we investigate the utility of the tropical freshwater snail, Biomphalaria glabrata and the marine owl limpet, Lottia gigantea, as alternative invertebrate systems to study endocrine diseases by identifying and analyzing the complete set of NR genes in their recently sequenced genomes. We identified 42 putative NRs in B. glabrata and 35 from L. gigantia, based on the presence of conserved regions. Many of the identified molluscan NRs have vertebrate orthologs. However, some NRs found in vertebrates are absent from these mollusc genomes, notably the members of subfamily 3C which includes some of the “vertebrate” steroid hormone targets, suggesting that these two molluscs may be inappropriate models for steroid hormone mediated mammalian endocrine function. Differences were also found between the two molluscs, including the thyroid hormone receptor of Group 1A, which, although absent in B. glabrata, was identified in L. gigantea, indicating that further investigation of molluscs as models of thyroid disease/dysfunction is warranted. The mollusc genomes also contain NR orthologs that are present in insects and nematodes but not in vertebrates, such as subfamily 1J and a 2DNA-binding domain NR. Phylogenetic analyses also revealed the presence of a unique and atypical subset of four NRs in B. glabrata. The presence of other vertebrate NR orthologs, however, raises the exciting possibility of shared significant pathways which could give an insight into mechanistic read-across between molluscs and mammals and provided insight into the evolutionary development of endocrine systems.
Nothing to Disclose: SK, AB, CJ, LN, ER, SJ, AL
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