Low bone mineral density and hypercholesterolemia in normal weighted children and adolescents

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 224-247-Osteoporosis I
Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-245
Han-Hyuk Lim*
Chungnam national university School of medicine, Daejeon, South Korea
Low bone mineral density and hypercholesterolemia in normal weighted children and adolescents

Han Hyuk Lim

Department of pediatrics, Chungnam national university School of medicine, Daejeon, Korea

Abstract

Introduction : Peak bone mass is achieved at the period of adolescents and young adults. The role of hypercholesterolemia in development of osteoporosis has been suggested in published reports. It is known that the high body mass index (BMI) are associated with increasing of bone mineral density (BMD). We investigated that hypercholesterolemia of non-obese children and adolescents may cause low BMD.

Patients and Methods: This study was based on data from Korea National Health and Nutritional Examination Survey 2009-2010. Five hundreds and twenty seven normal-weighted children and adolescents (266 male, 261 female; aged 10-18 years; -0.5<BMI-SDS<0.5) were enrolled. We analyzed correlation between hypercholesterolemia and metabolic components and BMD z-score.

Results: Serum cholesterol was shown weakly significant correlation with waist to hip ratio (WHR) (r=0.107, P-value=0.024). Male with high cholesterol had lower BMD z-score than normal cholesterol (toral femur, P=0.008; femoral neck, P=0.003; total lumbar spine, P=0.002), not female. But cholesterol levels had significantly negative correlation with BMD z-score in both sex (male, r2=0.040, P=0.002; female, r2=0.019, P=0.042).

Conclusions: The cholesterol may be an independent factor of low BMD in normal-weighted children and adolescents. Although children and adolescents are non-obese, we should regularly check their serum cholesterol levels for peak bone mass.

Nothing to Disclose: HHL

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm