Session: FP38-Physiological Impacts of Endocrine Disrupting Chemicals
Room 256 (Moscone Center)
Poster Board MON-339
The study (approved by the ethics committee) included fat biopsies from 30 volunteer Finnish boys that were referred for orchiopexy (cases) and 29 boys that were operated for inguinal hernia, abdominal hernia or hydrocele (controls) at Turku University Hospital in 2002 - 2006. During the operation, a subcutaneous fat biopsy was taken. In addition, the parents filled in a questionnaire concerning the breastfeeding of the child. Samples were analyzed for 37 PCBs, 17 PCDD/Fs and 14 PBDEs.
After the data was adjusted for postnatal confounders such as the age of the mother, total period of exclusive breastfeeding, age when the breastfeeding was discontinued and age when the child was operated, cryptorchid cases had significantly higher ∑PCDD/F (median case vs control 99.2 pg/g vs 63.2 pg/g, p=0.02) and the WHO-TEq of the 17 dioxins and 12 dioxin-like PCBs i.e. total-TEq (6.7 pg/g vs 4.1 pg/g, p=0.002) than controls. No significant association was found between congenital cryptorchidism and ∑PBDEs (6.6 ng/g vs 4.9 ng/g, p=0.53) or ∑PCB (68.5 ng/g vs 79.5 ng/g, p=0.06) in adipose tissue.
In conclusion, pre- and postnatal exposure to dioxin-like PCBs and PCDD/Fs might be associated with congenital cryptorchidism.
Nothing to Disclose: JJK, HEV, HK, KMM, NES, JT
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