Association of 25-OH-Vitamin D Levels and Bone Mineral Density with Arterial Stiffness in Relatively Healthy People: A Large Population-Based Cross-Sectional Study

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 248-267-Osteoporosis II
Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-257
Tao Yang*, Zhenxin Zhu, Mengdie Cao, Wei He, Min Sun, Mei Zhang and Qi Fu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Aim: Vitamin D deficiency and reduced bone mineral density have been reported to be predictive factors of arterial stiffness. But the existing researches did not get consistent results.We therefore investigated the association of serum 25-OH-vitamin D levels and bone mineral density with arterial stiffness in relatively healthy population.Methods: A total of 1549 Chinese adults (728 males; aged 40 to 78 yr.) in Nanjing were recruited in this cross-sectional study. Brachial-ankle pulse wave velocity (baPWV), calcaneus quantitative ultrasound (QUS) and serum 25-OH-vitamin levels were measured. Cardiovascular risk factors were evaluated.Results: The data showed that their relationships existed only in postmenopausal women, not in men or premenopausal women. Increased baPWV was correlated with reduced bone mineral density (r=-0.112, P=0.003), but theassociation was not significant when controlling for age levels. 25-OH-vitamin D was the independent factor of baPWV only in the second quartile group of T (-1.7≤T<-1)value (β=-0.138, P=0.025) or when serum VD value was below 10ng/mL (β=-0.322, P<0.001).Conclusion: Among postmenopausal women with reduced bone mass or 25-OH-vitamin D levels, vitamin D is a significant influential factor for arterial stiffness. Women with low bone mineral density who are postmenopausal may have a high risk of arterial stiffness.

Nothing to Disclose: TY, ZZ, MC, WH, MS, MZ, QF

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: This work was supported by a grant from the National Natural Science Foundation of China.