Session: MON 649-675-Central Regulation of Appetite & Feeding/GI Regulatory Peptides
Bench to Bedside
Poster Board MON-670
GLP-1 will exert a beneficial effect on glucose homeostasis in healthy, overweight human volunteers, and co-administration with PYY3-36 will not attenuate this response.
14 overweight healthy volunteers were studied in a single-blinded crossover fashion. They were randomised to receive four infusions: 1) vehicle; 2) GLP-1 at 0.2 pmol/kg/min; 3) PYY3-36 at 0.15 pmol/kg/min; and 4) co-infusion of GLP-1 plus PYY3-36 at the above doses. During each intervention, a Frequently Sampled Intravenous Glucose Tolerance Test was performed to assess acute insulin response to glucose (AIRg), and insulin sensitivity (Si), using Minimal Modeling.
AIRg was significantly increased by infusion of GLP-1 alone, compared to all other interventions (p<0.05). No acute effect on Si was noted with any of the interventions. The disposition index (AIRg ´ Si) was significantly greater following administration of GLP-1 alone than with any other intervention (p<0.05).
GLP-1 infusion increases the AIRg in healthy, overweight humans. In contrast, PYY infusion had no effect on AIRg and neither hormone, alone or in combination, was shown to enhance Si in the acute setting.
Nothing to Disclose: TT, VS, RT, AD, AA, SM, KB, MAG, JSM, BF, IFG, SRB
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
See more of: Abstracts - Orals, Featured Poster Presentations, and Posters