Session: SUN 678-689-Adipocyte Biology
Poster Board SUN-679
Objectives: To evaluate SAT, VAT and VAT / SAT ratio, by abdominal CT at: 1) in HIV-infected patients on cART vs. uninfected controls, 2) in patients with and without lipodystrophy defined clinically (CL) vs. controls, 3 ) in patients with lipodystrophy defined by fat mass ratio (FMR) defined by DXA vs controls.
Patients and methods: We evaluated 173 controls and 211 HIV-1 infected patients on cART. Anthropometric parameters and abdominal fat mass by CT [total fat mass (TFM), SAT, VAT and VAT/SAT, after adjustment for age and BMI] were analyzed.
Results: TFM and SAT were higher in controls, regardless the gender and VAT/SAT ratio was higher in HIV-infected female. When lipodystrophy was defined clinically, women without CL and controls had higher SAT; VAT/SAT ratio was higher in HIV-infected patients (with or without CL). In men, TFM and SAT was higher in controls and in those without CL; VAT/SAT ratio was higher in infected-patients (with or without CL). When lipodystrophy was defined by FMR, controls and women without lipodistrophy had higher SAT; VAT/SAT ratio was higher in HIV-infected women (with or without lipodystrophy). In men, TFM and SAT was higher in controls and in patients without lipodystrophy; VAT/SAT ratio was higher in HIV-infected patients (with or without lipodystrophy). Both gender with lipodystrophy had higher VAT.
Conclusion: HIV-infected patients had higher VAT/SAT ratio, regardless the gender and the definition of lipodystrophy used.
Nothing to Disclose: PF, ACS, AJM, EL, MJM, RS, SX, JP, AS, DC
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