HIV-1 INFECTED PATIENTS HAD HIGHER RATIO VAT/SAT, REGARDLESS THE DEFINITION OF LIPODYSTROPHY

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 678-689-Adipocyte Biology
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-679
Paula Freitas*1, Ana Cristina Santos2, António José Madureira3, Eva Lau1, Maria João Matos1, Rosário Serrão3, Sandra Xerinda3, Jorge Pereira3, António Sarmento3 and Davide Carvalho1
1Centro Hospitalar São João; Faculty of Medicine, Porto University, Portugal, 2Faculty of Medicine, Porto University, Portugal, 3Centro Hospitalar São João, Portugal
Introduction: Waist circumference (WC) is a marker of metabolic disturbances. WC reflects both abdominal subcutaneous (SAT) and visceral adipose tissue (VAT), which individually may have different contributions to metabolic changes. HIV-infected patients on  combined antiretroviral therapy (cART) may have alterations in body composition, which can result in different distribution of adipose tissue.

Objectives: To evaluate SAT, VAT and VAT / SAT ratio, by abdominal CT at: 1) in HIV-infected patients on cART vs. uninfected controls, 2) in patients with and without lipodystrophy defined clinically (CL) vs. controls, 3 ) in patients with lipodystrophy defined by fat mass ratio (FMR) defined by DXA vs controls.

Patients and methods: We evaluated 173 controls and 211 HIV-1 infected patients on cART. Anthropometric parameters and abdominal fat mass by CT [total fat mass (TFM), SAT, VAT and VAT/SAT, after adjustment for age and BMI] were analyzed.

Results: TFM and SAT were higher in controls, regardless the gender and VAT/SAT ratio was higher in HIV-infected female. When lipodystrophy was defined clinically, women without CL and controls had higher SAT; VAT/SAT ratio was higher in HIV-infected patients (with or without CL). In men, TFM and SAT was higher in controls and in those without CL; VAT/SAT ratio was higher in infected-patients (with or without CL). When lipodystrophy was defined by FMR, controls  and women without lipodistrophy had higher SAT; VAT/SAT ratio was higher in HIV-infected women (with or without lipodystrophy). In men, TFM and SAT was higher in controls and in patients without lipodystrophy; VAT/SAT ratio was higher in HIV-infected patients (with or without lipodystrophy). Both gender with lipodystrophy had higher VAT.

Conclusion: HIV-infected patients had higher VAT/SAT ratio, regardless the gender and the definition of lipodystrophy used.

Nothing to Disclose: PF, ACS, AJM, EL, MJM, RS, SX, JP, AS, DC

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm