PREVALENCE OF ORTHOSTATIC HYPERTENSION AND ITS ASSOCIATION WITH METABOLIC AND ECHOCARDIOGRAPHIC PARAMETERS IN ELDELY PATIENTS WITH TYPE 2 DIABETES

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 807-838-Diabetes - Diagnosis, Complications & Outcomes
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-810
Patricia Mesquita, Deborah Queiroz, Juliana Maia, Manoel Aderson Soares Filho*, Jessica Garcia, Alexsandro da Silva, Ana Claudia Torquato and Francisco Farias Bandeira
Division of Endocrinology, Diabetes and Bone Diseases, Agamenon Magalh„es Hospital, University of Pernambuco Medical School, Recife, Brazil
INTRODUCTION

Cardiovascular autonomic neuropathy is associated with significant morbidity and mortality in patients with type 2 diabetes (T2D) with orthostatic hypotension being the most dangerous complication.

Orthostatic hypertention (OHT) has been reported to occur, but studies assessing its effects on health outcomes especially in elderly and diabetics are scarce. The definition, prevalence and its effect on cardiovascular safety is still controversial.

OBJECTIVE

The aim of the present study was to determine the prevalence of OHT in enderly patients with type 2 diabetes and its association with metabolic factors, echocardiographic parameters, and chronic complications.

METHODS

An analytic cross-sectional study in 97 diabetic patients aged > 60 yr (mean 68,97 +- 6,80 yr), normotensive or hypertensive on angiotensin converting enzyme inhibitors, angiotensin receptor blockers or calcium channel blockers only. OHT was defined as a ≥ 10mmHg increase in systolic blood pressure after 4 minutes in standing against the sitting position

RESULTS

Mean duration of diabetes was 12,23 yr (±8,34) and HbA1C was 7,9% (±1,71).  The prevalence of OHT was 20,6%. Mean BMI was significantly higher in pacients with OHT in comparation with those without it (29.80 ±4.10 vs. 27.51 ±3.98kg/m2, p=0.026) as was hip circumference  (106.00 ±13.16 vs. 100.59 ±8.56cm, p=0.029). There were no statisticaly significant difference between the two groups in other metabolic paramethers such as waist circumference, serum trigliceryde, HDL-c and HbA1C.

Among the 68 patients who did an  echocardiographicy examination 27% from those who had OHT had increases in index left atrial volume (iLAV)in comparation with 75% of those who did not have OHT (p=0,004).   The average iLAV of patients with OHT was significantly lower in comparation to those without OHT (26.27 ±6.37 vs. 32.65 ±7.54 respectively, p=0.011).

CONCLUSION

Our data sugests some protective cardiac effect of postural increases in blood pressure in long standing T2D.

Nothing to Disclose: PM, DQ, JM, MAS, JG, AD, ACT, FFB

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm