Increased insulin resistance but without obesity patient in korea

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 677-696-Obesity Physiology & Epidemiology
Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-681
Sangmo Hong*1, Chang-Bum Lee2, Dong-Sun Kim3, Yongsoo Park4, You Hern Ahn5 and Woong Hwan Choi6
1Hanyang University, Gyeonggi, South Korea, 2Hanyang Univ, Guri, South Korea, 3Hanyang Univ, Seoul, South Korea, 4Hanyang Univ., College of Engine, Seoul, South Korea, 5Hanyang University Hospital, 6Hanyang Univ Hospital, Seoul, South Korea
Lipodystrophy is a disease characterized by low fat mass and increased insulin resistance. In actual clinical practice, some patients, with insulin resistance but low fat mass, share the characteristics of lipodystrophy patients. Prevalence and characteristics of these similar lipodystrophy in Korea are not well known.

Korea representative data, the National Health and Nutrition Examination Survey 2010 data from the present study analyzed the prevalence and characteristics of the country of similar fat dystrophy. We made Z-score of fat mass index [body fat mass (kg) / (Height (m)2] with LMS method. We defined lypodystropy-like patients as not obese (BMI< 25kg/m2 and waist circumference < 90 cm (male), < 85 cm(female), and Z score for fat mass index below 0) and insulin resistance (with metabolic syndrome). Metabolic syndrome followed the NECP criteria.

The prevalence of metabolic syndrome whose BMI was below 25 kg/m2 was 11.4% (over the age of 20) and 38.4% (over the age of 65). And the prevalence of lypodystropy-like patients was 6.8% (over the age of 20) and 20.4% (over the age of 65). HOMA-IR of lypodystropy-like patients (2.17±1.37) was significant higher than people without metabolic syndrome (1.91±1.83, p<0.001) and was significant lower than with patients with metabolic syndrome and without lypodystropy feature (2.78±2.16).

In this study, a lot of patients showed the lypodystropy-like feature. They showed increased insulin resistance without the relationship with obesity.

Nothing to Disclose: SH, CBL, DSK, YP, YHA, WHC

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm