Session: SUN 414-431-HPT Axis Biology
Poster Board SUN-415
RESEARCH DESIGN AND METHODS A total of 205 euthyroid prediabetic patients who underwent regular health check-up in 2012 at Severance Hospital, Seoul, Korea were included in this cross-sectional, retrospective study. Prediabetes was defined as A1c between 5.7 and 6.4% or fasting blood glucose (FBG) between 100 and 125 mg/dL. A1c and glycated albumin levels were measured in these patients. TFT (free T4, T3, TSH), A1c, GA, FBG, and lipid profiles was checked.
RESULTS In this euthyroid, prediabetic population, A1C levels did not correlate with TSH level. However, GA was significantly correlated with TSH level. (r=0.432, p value < 0.01) Furthermore, after adjusting for confounding parameters affecting GA, such as glucose level, multiple linear regression analysis showed that GA is independently associated with TSH. (β = 0.312, p value < 0.05)
CONCLUSIONS While A1c was not associated with TFT results in prediabetic patients, GA was positively associated with TSH. Therefore, thyroid function does not affect the A1c-based classification of prediabetes. However, GA, which is another marker of glycemic control, is influenced by thyroid function, which limits its use in screening for prediabetes.
Nothing to Disclose: YC, DYS, KJK, HP, KHP, SH, EJL
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