HIGH PREVALENCE OF VITAMIN D DEFFICIENCY AND ITS ASSOCIATION WITH METABOLIC SYNDROME IN ELDERLY MEN LIVING IN THE TROPICS

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Basic/Translational
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-264
Marcelo Cabral, Juliana Maia, Manoel Aderson Soares Filho, Leonardo Bandeira and Francisco Farias Bandeira*
Division of Endocrinology, Diabetes and Bone Diseases, Agamenon Magalh„es Hospital, University of Pernambuco Medical School, Recife, Brazil
INTRODUCTION

An inverse association between serum 25OHD levels and metabolic syndrome (MS) has been proposed, but the data so far are controversial especially related to the cut point used.

OBJECTIVE

The aim of the present study was to determine the prevalence of vitamin D deficiency among elderly men and its association with metabolic syndrome in the city of Recife, Brazil (8oS).

METHODS

We evaluated the serum levels of 25OHD, sun index and metabolic risk factors in 284 men (age +-SD 69.44 yr ±6.49) attending primary care clinics.

RESULTS

Mean serum 25OHD was 27.87±13.52 ng/ml, BMI 25.67 ±4.31 Kg/m2 and sun index (hours of sun exposure per week x fraction of body surface area exposed) 5.49 ±5.05. The prevalence of vitamin D deficiency was 31.5% (95% CI 26.2-36.8) and 66.7% (95% CI 61.3-72.1) when cutoff of less than 20ng/ml and 30ng/ml were used, respectively. 70,5% had hypertension; 64,2% high fasting plasma glucose (≥ 100mg/dL); 42,3% had high triglycerides (≥150 mg/dL); 47,4% low HDL-c (<40 mg/dL); 58,7% increased waist circumference according to IDF criteria (>94cm) and 32,4% according to NCEP (> 102cm).

When evaluating the number of criteria for MS (NCEP) we found that: 4,4% didn't have any; 17,6% had one; 23,4% had two; 30,8% had three; 19,8% had four and 4,0% had five. Among patients with no MS criteria, 50% had 25OHD<30ng/mL and 24% < 20ng/mL. In contrast, for those with 5 MS criteria, 72,7% had 25OHD <30ng/mL and 36,4% < 20ng/mL.

In a univariate analysis, patients who had 25OHD <20ng/ml, had mean sun index lower than those with >20ng/ml (4,46 ±3,69 vs 6,01 ±5.4; p=0.006) and this association was not statistically significant using the cutoff of 30ng/ml (5,22 ±4,43 vs 6,12 ±6,14; p=0.180). Patients with 25OHD <20ng/ml presented higher mean BMI than those with >20ng/ml (25,91 ±4,73 vs 24,95 ±4,21; p=0.045) and this was also true for those with 25OHD <30ng/ml (26,12 ±4,92 vs 25,08 ±4,19; p=0.018).

After adjustment for possible confounders by multiple regression analyses, sun index was independent and positively associated with serum 25OHD levels (p=0,005); BMI and presence of MS (NCEP) were independent and inversely associated with serum 25OHD levels (p=0,005 and p=0,007, respectively).

CONCLUSION

Our data suggest that regular sun in elderly exposure without protection in daily life doesn’t protect against 25OHD levels > 30ng/ml and that vitamin D deficiency was independently associated with metabolic risk.

Nothing to Disclose: MC, JM, MAS, LB, FFB

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm