DIFFERENTIAL PROXIMAL (GIP) AND DISTAL (GLP-1) GUT PEPTIDE RELATIONSHIP TO SATIATION IN RESPONSE TO DIET COMPOSITION AND EXERCISE

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 824-833-GI Regulatory Peptides
Bench to Bedside
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-824
Po-Ju Lin*1 and Katarina T Borer2
1University of Michigan, Ann Arbor, MI, 2Univ of Michigan, Ann Arbor, MI
It is unclear how gut peptides influence human satiation in response to different diet composition and exercise. We examined the relationship of changes in gastric inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1) and satiation in response to meals of Paleolithic (P) versus Western diet (W) composition, and exercise (X) versus sedentary (S) condition.

PURPOSE: Examine the effect of P and W meals on fullness ratings and plasma GIP and GLP-1 concentrations during X or S condition. 

METHODS: Thirty-Two healthy postmenopausal women were assigned to 1 of 4 conditions: S or 2 bouts of 2h of X (7 to 9 h and 14 to 16 h) with P or W meals (PS, PX, WS, WX; n=8 each) provided at 10 h and 17 h..  The P meal contained 30% carbohydrate (CHO), 25% protein (PRO), and 45% FAT while W meal contained 60% CHO, 15% PRO, and 25% FAT. Plasma GIP and GLP-1 concentrations were measured by chemiluminescence, and hunger and fullness ratings were assessed with a visual analog scale, at hourly intervals during postprandial periods (PPs).  Using repeated-measures mixed model of ANOVA, we analyzed the correlation between plasma GIP and GLP-1 concentrations and satiation during two postprandial periods. 

RESULTS:  GIP and GLP-1 relationship to satiation differed during the two PPs and in response to X, W and P. Satiation was unaffected by W,P or X. A strong GIP correlation with satiation during the first PP was unaffected by W,P or X. However, during the second PP, GIP relationship to satiation remained unchanged to W while it was significantly reduced to P, and neither response was affected by X. In contrast, GLP-1 response also reflected the changes in satiation. It appeared unaffected by diet composition but was increased in response to X during both PPs.

CONCLUSION: While there was a correlation between satiation and secretory pattern of  both gut peptides, type of diet, exercise and order of postprandial periods affected GIP and GLP-1 responses differentially.

Nothing to Disclose: PJL, KTB

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: NIDDK grant R15 DK082800 and Blue Cross Blue Shield student award.
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