Session: SAT 824-833-GI Regulatory Peptides
Bench to Bedside
Poster Board SAT-824
PURPOSE: Examine the effect of P and W meals on fullness ratings and plasma GIP and GLP-1 concentrations during X or S condition.
METHODS: Thirty-Two healthy postmenopausal women were assigned to 1 of 4 conditions: S or 2 bouts of 2h of X (7 to 9 h and 14 to 16 h) with P or W meals (PS, PX, WS, WX; n=8 each) provided at 10 h and 17 h.. The P meal contained 30% carbohydrate (CHO), 25% protein (PRO), and 45% FAT while W meal contained 60% CHO, 15% PRO, and 25% FAT. Plasma GIP and GLP-1 concentrations were measured by chemiluminescence, and hunger and fullness ratings were assessed with a visual analog scale, at hourly intervals during postprandial periods (PPs). Using repeated-measures mixed model of ANOVA, we analyzed the correlation between plasma GIP and GLP-1 concentrations and satiation during two postprandial periods.
RESULTS: GIP and GLP-1 relationship to satiation differed during the two PPs and in response to X, W and P. Satiation was unaffected by W,P or X. A strong GIP correlation with satiation during the first PP was unaffected by W,P or X. However, during the second PP, GIP relationship to satiation remained unchanged to W while it was significantly reduced to P, and neither response was affected by X. In contrast, GLP-1 response also reflected the changes in satiation. It appeared unaffected by diet composition but was increased in response to X during both PPs.
CONCLUSION: While there was a correlation between satiation and secretory pattern of both gut peptides, type of diet, exercise and order of postprandial periods affected GIP and GLP-1 responses differentially.
Nothing to Disclose: PJL, KTB
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