THE EFFECTS OF INTERMITTENT VITAMIN D3 SUPPLEMENTATION ON MUSCLE STRENGTH AND METABOLIC PARAMETERS IN POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES: A RANDOMIZED CONTROLLED STUDY

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Basic/Translational
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-262
Roseane Silva, Luiz Henrique Griz, Juliana Maia, Manoel Aderson Soares Filho, Maria Paula Bandeira and Francisco Farias Bandeira*
Division of Endocrinology, Diabetes and Bone Diseases, Agamenon Magalh„es Hospital, University of Pernambuco Medical School, Recife, Brazil
INTRODUCTION

The association between vitamin D deficiency and the development of metabolic syndrome and type 2 diabetes as well as decreased skeletal muscle mass has been reported but the effects of vitamin D supplementation on these parameters is still controversial.

OBJETIVE

To evaluate the effect of weekly vitamin D3 supplementation on metabolic parameters and muscle strength of postmenopausal women with type 2 diabetes.

METHODS

38 patients with serum 25OHD < 30 ng/ml were randomly assigned to oral vitamin D3 (6600IU/week in 2 cc oil preparation) or 2cc olive oil weekly for 3 months with the study medication being administered under supervision in all subjects.

RESULTS

Baseline characteristics in the intervention and control groups were: age 62.16 ± 7.62 vs 62.32 ± 8.00 years (p= 0.9), diabetes duration 11.1 ± 7.4 vs 8.95 ± 7.4 years (p=0.36), BMI 27.6 ± 5.3 vs 28.2 ±5.9 Kg/m2 (p=0.6), HbA1c 8.18 ± 2.13 vs 9.13 ± 2.12 % (p= 0.15), serum 25OHD 22.24 ± 3.98 vs 22.91 ± 4.21 ng/ml (p=0.6), with differences in sun index, BP, FPG, and serum lipids. At the end of treatment period 26% of the intervention and 48% of the control groups had 25OHD < 20 ng/ml. Handgrip strength improved significantly in the intervention group (right arm 17.4 ± 2.68 to 19.9 ± 3.53 Kg, p= 0.002; left arm 16.31 ± 2.6 to 18.46 ± 3.2 Kg, p< 0.001) but not in the control group (right arm 16.87 ± 3.99 to 17.93 ±  4.91 Kg, p= 0.1; left arm 16.13 ± 4.29 to 16.86 ±  4.79 Kg, p< 0.2). There were no significant differences in the distribution of BMI at baseline but more patients in the control group became obese at the end of the study period (p=0.014). There were no significant changes in mean FPG (155.5 ± 67.4 to 163.4 ± 87.9 mg/dl, p=0.7), PPG 213.5 ± 87.7 to 210.7 68.8 mg/dl, p=0.8), HbA1c (8.18 ± 2.13 to 8.67 ± 2.41 %, p=0.1), serum triglycerides (175.68 ± 86.5 to 169.63 ± 62.17 mg/dl, p=0.9), SBP (136.3 ± 12.7 to 139.42 ± 4.2 mmHg, p=0,4) and DBP (81.3 ± 7.4 to 83.0 ± 10.0 mmHg, p=0.4) with vitamin D supplementation. SBP increased significantly in the control group from 136.6 ± 18.6 to 141.4 ± 17.6 mmHg (p=0.04).

CONCLUSION

Vitamin D3 supplementation in doses equivalent to 942 IU/day improved isometric handgrip strength but had no effect on glycemic control in postmenopausal women with longstanding type 2 diabetes.

Nothing to Disclose: RS, LHG, JM, MAS, MPB, FFB

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm