Session: MON 796-817-Diabetes Genetics & Epidemiology
Poster Board MON-805
The aim of this study was to examine if the Maya population presents five common genetic variants previously associated with T2D. The project was approved by the “Human research ethical Committee” of Hospital Juárez de Mexico. We analyzed 575 individuals from 22 Maya communities from the Yucatan Peninsula. Genotyping was performed by RT-PCR. Evaluation of genetic ancestry group was included. Results showed an association of ABCA1 rs9282541 with T2D, OR= 2.29 (95% CI 1.337-3.929 p=0.003); the allele frequency of ABCA1 risk variant was 20.43 %, in agreement with previous studies done in Mexican Mestizos. In addition, HNF4A rs1800961 was associated with high triglyceride concentration. HNF4A rs1800961 and PPARG rs1801282 frequencies were 10.9% and 17.2% respectively; both were higher than those reported in the HapMap. The allele frequency of HHEX rs1111875 was 42.1%, which is higher than those reported in HapMap, except the Asian population. The frequency of KCNJ11 rs5219 was 34.6%, which was higher than those reported by the 1000 genomes project. Finally, this study reveals that ABCA1 rs9282541 is associated with T2D in Maya population. In addition, the high frequency of SNPs rs1111875, rs5219, rs1800961 and rs1801282 suggest that may have an effect on susceptibility to develop T2D in Maya population, however will be necessary to search for other factors that may explain diabetes in Mexico.
Nothing to Disclose: JL, MGO, BIP, IM, JC, MP, LC, MDLG, MM
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