Session: MON 238-262-Vitamin D Action, Deficiency & Disorders
Bench to Bedside
Poster Board MON-251
Methods: This was a retrospective, cross-sectional study analyzing the data of 442 patients whose serum 25(OH)D3 level was measured in euthyroid state. Thyroid ultrasonography, measurement of thyroid autoantibody (TPOAb, thyroglobulin Ab), and thyroid function test (TFT) was performed while simultaneous measuring serum 25(OH)D. Patients were excluded if diffuse thyroiditis was suspected on ultrasonography or if positive for thyroid autoantibodies.
Results: After dividing the patients into two groups- TSH level greater or less than 2.5 mIU/L, the mean level of serum 25(OH)D3 was higher in patients with TSH less than 2.5 mIU/L (21.3 vs 15.2 mIU/L, p-value <0.05). Also, the level of 25(OH)D3 was negatively associated with TSH (r=-0.278, p value < 0.01). After setting TSH as a dependent variable and adjusting for age, gender, BMI, and free T4, 25(OH)D3 still maintained a negative association with TSH (β = -0.223, p-value <0.05).
Conclusions: 25(OH)D3 and TSH was negatively correlated even in euthyroid population. This implies that 25(OH)D3, as a modulator of autoimmunity, is capable of influencing thyroid function in subjects without thyroiditis.
Nothing to Disclose: DYS, KJK, HP, KHP, SH, EJL
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
See more of: Abstracts - Orals, Featured Poster Presentations, and Posters