Clinical, Hormonal and Metabolic Profiles of Subclinical Hypothyroidism in Reproductive- age Saudi Women with Polycystic Ovary Syndrome

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 532-553-Hyperandrogenic Disorders
Basic/Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-537
Saleh Ahmad Alasiri*
King Saud University, Riyadh, Saudi Arabia
Clinical, Hormonal and Metabolic Profiles of Subclinical Hypothyroidism in Reproductive- age Saudi Women with Polycystic Ovary Syndrome

 

Saleh A. AlAsiri, MD, FRCSC, FACOG, Assistant Professor and Director, IVF and Assisted Reproductive Technologies Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia

Objective: to elucidate the relationship between important clinical, hormonal and metabolic indices in reproductive-age Saudi women with polycystic ovary syndrome (PCOS) and normal thyroid function or subclinical hypothyroidism (SCH).

Design: A retrospective study

Setting: University -based Reproductive Endocrinology and Infertility Clinic

Patients: Young Saudi women diagnosed with PCOS according to the Rotterdam criteria (n= 117)

Intervention(s) : assessment of clinical, hormonal and metabolic indices. Subclinical hypothyroidism was defined as serum TSH levels of 5 -10 mIU/L.

Results:

The mean age of the study population was 28 ± 5.3 years. Mean body mass index was 31.5 ± 7.0 kg/m2. Among the 117 subjects, normal thyroid function was detected  in 97 women ( 82.9%) while 20 women (17.1%) had SCH. Out of all the parameters studied, only serum levels of dehydroepiandrosterone sulfate  ( 5.5 ± 1.6 µmol/L  in women with normal thyroid compared with  4.5 ± 1.7 µmol/L in women with SCH; t= 2.06, p= 0.04 ) and antral follicular count  ( 20.9 ± 10.6 in women with normal thyroid compared with 27.2 ± 9.8 in women with SCH; t=2.27, p= 0.02) were statistically significantly different between normal thyroid and SCH women.

Conclusion(s):

 In reproductive –age Saudi women with PCOS, SCH is associated with increased serum levels of DHEAS and AFC. This could suggest that PCOS with SCH is associated with greater adrenal and ovarian perturbation.

Nothing to Disclose: SAA

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