Session: SUN 758-779-Cardiometabolic Risk & Vascular Biology
Poster Board SUN-779
Methods: Consecutive 144 girls with polycystic ovary morphology on ovarian USG (age 11-18 years) were divided into 2 groups: obese (OBS, BMI 30+/- 0.5) and with normal BMI (NOR, BMI 22=/- 0.3). In all girls we took a medical history, obtained anthropometric measurements, complete physical examination and detailed biochemical and endocrine profile. Then, we measured glycemic and insulinemic response (INS, mUI/ml) to 75g OGTT.
Results: Fasting plasma glucose was normal in all girls, in both study groups. However, 27% of the OBS participants met the criteria for impaired glucose tolerance diagnosis. All tested girls had various degree of hyperandrogenemia. Fasting and post challenge insulin, insulin resistance (IR-HOMA) and leptin levels were significantly higher in the obese PCO girls.
Group: NOR OBS
BMI 22 ± 0.3 30 ± 0.5*
SBP (mm Hg) 106.5 ± 2.4 126.5 ± 1.5*
Fasting insulin (mUI/ml) 13 ± 0.7 22 ± 1.0*
OGTT -120 min insulin 88 ± 4 194 ±14*
IR-HOMA 2.9 ± 0.2 5.1 ± 0.3 *
Adiponectin (mg/ml) 11.4 ± 1.6 5.8 ± 1.3 *
Leptin (ng/ml) 8.5 ± 2.3 24.1 ± 4.2*
- *P < 0.01
Conclusion: Although the metabolic interrelationship between obesity and PCOS development have not yet to be fully understood, the co-occurrence of significant differences in adipokines, namely dramatically low levels of adiponectin and high levels of leptin, and severe peripheral insulin resistance in adolescent girls could have a significant impact on fertility and emerges as an important risk factor of developing cardiovascular complications early in life.
Nothing to Disclose: MIB, MW, JS
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