Cardiometabolic risks are present in adolescent girls with polycystic ovaries morphology

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 758-779-Cardiometabolic Risk & Vascular Biology
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-779
Marianna I Bak*1, Malgorzata Walewska-Wolf2 and Jolanta Szufladowicz-Wozniak2
1Warsaw Med Univ, Warsaw, Poland, 2The Children's Memorial Health Institute, Warsaw, Poland
Background: PCOS does not become clinically visible until early adolescence; however, its origins are likely much earlier. Insulin resistance emerges as an important factor reflecting early signs of PCOS in women. Therefore identifying the subset of girls with polycystic ovary morphology may provide data not only regarding the mechanisms for the development of PCOS but also could explore the role of insulin resistance as an early factor for cardiovascular diseases in young adults.

Methods: Consecutive 144 girls with polycystic ovary morphology on ovarian USG (age 11-18 years) were divided into 2 groups: obese (OBS, BMI 30+/- 0.5) and with normal BMI (NOR, BMI 22=/- 0.3). In all girls we took a medical history, obtained anthropometric measurements, complete physical examination and detailed biochemical and endocrine profile. Then, we measured glycemic and insulinemic response (INS, mUI/ml) to 75g OGTT.

Results: Fasting plasma glucose was normal in all girls, in both study groups. However, 27% of the OBS participants met the criteria for impaired glucose tolerance diagnosis. All tested girls had various degree of hyperandrogenemia. Fasting and post challenge insulin, insulin resistance (IR-HOMA) and leptin levels were significantly higher in the obese PCO girls.  

Group:                                               NOR                     OBS                   

BMI                                                    22 ± 0.3               30 ± 0.5*

SBP (mm Hg)                                    106.5 ± 2.4         126.5 ± 1.5*

Fasting insulin (mUI/ml) 13 ± 0.7               22 ± 1.0*

OGTT -120 min insulin                    88 ± 4                   194 ±14*

IR-HOMA                                          2.9 ± 0.2              5.1 ± 0.3 *

Adiponectin (mg/ml)                      11.4 ± 1.6            5.8 ± 1.3 *

Leptin (ng/ml)                                  8.5 ± 2.3              24.1 ± 4.2*

  • *P < 0.01

Conclusion: Although the metabolic interrelationship between obesity and PCOS development have not yet to be fully understood, the co-occurrence of significant differences in adipokines, namely dramatically low levels of adiponectin and high levels of leptin, and severe peripheral insulin resistance in adolescent girls could have a significant impact on fertility and emerges as an important risk factor of developing cardiovascular complications early in life.

Nothing to Disclose: MIB, MW, JS

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

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