ONE IN FIVE OF HIV-1-INFECTED PATIENTS HAVE HYPOGONADISM

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 554-583-Male Reproductive Endocrinology & Case Reports
Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-562
Paula Freitas*1, Ana Cristina Santos2, Eva Lau1, António José Madureira3, Maria João Matos1, Sandra Xerinda3, Rosário Serrão3, António Sarmento3 and Davide Carvalho1
1Centro Hospitalar São João; Faculty of Medicine, Porto University, Portugal, 2Faculty of Medicine, Porto University, Portugal, 3Centro Hospitalar São João, Portugal
Introduction: HIV associated hypogonadism is a prevalent endocrine disorder of multifactorial etiology.

Objectives: To study the prevalence of hypogonadism in HIV-1-infected males on combined antiretroviral therapy (cARTc) and its association with body composition and risk factors.

Patients and methods: we evaluated anthropometric and clinical parameters, body composition [fat mass (SAT, VAT and VAT/SAT ratio) by abdominal CT], viral load, CD4+  cell count and hormonal profile (SHBG, total testosterone, free testosterone, FSH, LH and leptin), in 155 HIV-1-infected patients on cART.

Results: The patients had 46.0 (39.0-53.0) years old, BMI 24.4 (22.5-27.3) kg/m2; 7.0 years of HIV infection duration (5.0 -10.0) and 6.0 (4.0-10.0) y duration of cART. 19.3% (n = 30) had biochemical hypogonadism. No statistically significant differences were found between patients with or without biochemical hypogonadism regarding age, weight, BMI, circumferences (neck, waist, hip, thigh and arm), presence of lipodystrophy (defined by clinical and by fat mass ratio) and  total fat mass, VAT, VAT/SAT ratio; years of HIV infection, duration of cART, CD4+ cell count, viral load suppression, leptin and SHBG levels, hypertension and consumption of alcohol or tobacco. Patients with hypogonadism had higher SAT [121.4 (69.8-185.9) vs. 78.0 (48.9-125.2) cm2, p = 0.046].  Total testosterone was negatively associated with age, BMI, total fat mass, VAT, SAT and leptin and was not influenced by age group or presence of lipodystrophy; free testosterone was negatively associated with age, total fat mass , SAT and leptin and did not vary by age group or presence of lipodystrophy; SHBG was negatively associated with BMI, total fat mass, VAT, SAT and VAT/SAT ratio and did not vary by age group or presence of lipodystrophy.

Conclusion: The biochemical hypogonadism was diagnosed in 19.3% of patients.

Nothing to Disclose: PF, ACS, EL, AJM, MJM, SX, RS, AS, DC

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm