Session: SUN 88-129-Acromegaly & Prolactinoma
Poster Board SUN-108
Patients and methods: Forty-four acromegaly patient and 43 age, sex and body mass index (BMI) matched healthy controls were included. BMI, waist-to-hip ratio (WHR) measurements and body composition analysis with bioelectrical impedence analysis method were done to all participants. Plasma CRP, fibrinogen, insulin, vaspin levels were tested. HOMA-IR were calculated for each participant.
Results: Waist circumference (WC), WHR, fat-free mass, total body water, HOMA-IR, fibrinogen, vaspin, were found to be significantly higher in acromegaly group than the healthy controls (p=0.003, 0.028, 0.038, 0.039, 0.012, <0.001, 0.006 respectively). Controlled acromegaly (CA) group had significantly higher WC, WHR, BMI, fat mass, fat % and CRP than the active acromegaly (AA) group (p=0.001, <0.001, 0.003, 0.005, 0.015, <0.001, respectively). Circulating vaspin levels in acromegalics showed significant positive correlation with IGF-1 (p=0.015 ve r=0.366).
Conclusion: This study is the first study in literature defining the increased levels of serum vaspin levels in acromegaly. Further studies are needed to explain the underlying pathophysiologic mechanisms.
Disclosure: AC: Consultant, Novartis Pharmaceuticals, Speaker, Novartis Pharmaceuticals, Speaker, Sanofi, Consultant, Sanofi, Speaker, Astra Zeneca, Speaker, Bristol-Myers Squibb, Consultant, Novo Nordisk, Speaker, Novo Nordisk, Speaker, Eli Lilly & Company. Nothing to Disclose: MY, AG, CB, DC, HE, MS
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
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