Serum Vaspin Levels in Acromegaly Patients

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 88-129-Acromegaly & Prolactinoma
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-108
Merve Yilmaz1, Arzu Gedik2, Can Basaloglu1, Dilek Cimrin1, Hulya Ellidokuz1, Mustafa Secil1 and Abdurrahman Comlekci*3
1Dokuz Eylul University Medical School, Izmir, Turkey, 2Dokuz Eylul Universitesi Tip Fak, Izmir, Turkey, 3Dokuz Eylul University, School of medicine, Izmir, Turkey
Introduction: In acromegaly patients, the overall cardiovascular risk is increased due to presence of several classical risk factors such as insulin resistence (IR), diabetes (DM), dyslipidemia and hypertension. Adipose tissue is an active endocrine organ which has a role in pathogenesis of atherosclerosis, DM and IR via its adipocytokines. Increased GH in acromegaly has several effects on adipocytokines secreted from the adipose tissue. In this study we aimed to evaluate circulating levels of vaspin is an adipocytokine with potential effects on IR and cardiovascular functions- and the possible association of vaspin with IR and cardiovascular risk factors.

Patients and methods: Forty-four acromegaly patient and 43 age, sex and body mass index (BMI) matched healthy controls were included. BMI, waist-to-hip ratio (WHR) measurements and body composition analysis with bioelectrical impedence analysis method were done to all participants. Plasma CRP, fibrinogen, insulin, vaspin levels were tested. HOMA-IR were calculated for each participant.

Results: Waist circumference (WC), WHR, fat-free mass, total body water, HOMA-IR, fibrinogen, vaspin, were found to be significantly higher in acromegaly group than the healthy controls (p=0.003, 0.028, 0.038, 0.039, 0.012, <0.001, 0.006 respectively). Controlled acromegaly (CA) group had significantly higher WC, WHR, BMI, fat mass, fat % and CRP than the active acromegaly (AA) group (p=0.001, <0.001, 0.003, 0.005, 0.015, <0.001, respectively). Circulating vaspin levels in acromegalics showed significant positive correlation with IGF-1 (p=0.015 ve r=0.366).

Conclusion: This study is the first study in literature defining the increased levels of serum vaspin levels in acromegaly. Further studies are needed to explain the underlying pathophysiologic mechanisms.

Disclosure: AC: Consultant, Novartis Pharmaceuticals, Speaker, Novartis Pharmaceuticals, Speaker, Sanofi, Consultant, Sanofi, Speaker, Astra Zeneca, Speaker, Bristol-Myers Squibb, Consultant, Novo Nordisk, Speaker, Novo Nordisk, Speaker, Eli Lilly & Company. Nothing to Disclose: MY, AG, CB, DC, HE, MS

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm