Session: SUN 758-779-Cardiometabolic Risk & Vascular Biology
Poster Board SUN-777
Puberty is associated with a physiologic inflammatory condition, in part due to the reduced insulin sensitivity observed at this age. The inflammatory markers profile, and their relationship with insulin levels has not been established in healthy children.
To compare inflammatory markers (IM) profile between pubertal vs prepubertal normal children and their correlation with Insulin levels.
Subjects y Methods
113 healthy children with normal weight and blood pressure of 10.59 ± 2.82 years old, 55.8% female, 58.4% pubertal were studied. Height and pubertal staging were registered. A fasting blood sample to determinate Alpha tumoral necrosis factor (TNF α), Interleukin 6 (IL6) and 8(IL8), plasminogen activator inhibitor-I (PAI I), Adiponectin (Ad), Ultrasensitive reactive C protein (usRCP) and Insulin (Ins) levels was obtained . Differences between these parameters by age, gender, puberty and their correlation with Ins levels were analyzed.
PAI-I (median and intequartile range) was 8,51 ( 5,66-15,68) and 14,72 (10,22-22,56) ng/ml in prepubertal and pubertal children respectively (P:0,0006). Ad was 14,2 (12,6-18,2) vs. 12,65 (9,6-15,3) ug/ml in prepubertal and pubertal children respectively (p: 0,015). Ad differences were observed only in boys.
No significant differences were observed in TNF α, IL6, IL8, and usRCP by age, gender or pubertal state.
No significant correlation were demonstrated between TNF α, IL6, IL8, usRCP, and Ad with BMI.
Levels obtained for the inflammatory parameters were: TNF α: 17,32 pg/ml (12,6-24,23) , IL6: 11,85 pg/ml (8,33-14,6), IL8: 19,45 pg/ml (16,04-28,21), usRCP: 0,29 mg/l (0,2-0,77). Ins was 8,1 u/ml (6,2-9) and was not correlated with age, puberty, BMI, PAI I or Ad.
Inflammatory state is higher during puberty according to PAI-I and Adiponectin levels independently of insulin concentration in normal children .
This suggests that these could be the most sensitive markers for estimate endothelial dysfunction in adolescents.
Values obtained in this normal population, may be useful as a reference in clinical practice.
Supported by Chilean grants: FONDEF D08i1087, FONDEF IDeA CA12i10150, FONDECYT 1100356 & 1130427 & IMII P09/016-F.
Nothing to Disclose: HG, CF, AM, MA, CA, CAL, LB, CAC, CC, RB, CF
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
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