Session: SAT 660-676-Clinical Obesity Treatment
Poster Board SAT-676
Obesity has become a global public health problem. It is associated with insulin resistance and metabolic syndrome (MetS) which can subsequently lead to development of diabetes mellitus and cardiovascular diseases. In comparison to therapeutic lifestyle changes, bariatric surgeries have been associated with profound and sustained weight loss which translates into improvement in metabolic parameters. It has been suggested that weight loss after bariatric surgery varies between ethnic groups. The aim of our study was to examine effect of ethnic origin and gender on weight loss after gastric bypass surgery. We also analyzed effect on MetS components.
We conducted retrospective analysis of components of MetS at baseline and at 12 months for subjects who underwent gastric bypass surgery between 01/01/2008 and 01/31/2011 at UTMB. AHA/NHLBI MetS definition was used to determine prevalence of MetS and its components at baseline and during follow up. BMI cut off of 25 kg/m2was used in place of waist circumference.
Total 201 consecutive subjects (Male: 38, Female: 163, Age: 47.5 ±10.4 years) who underwent gastric bypass surgery were included. Majority of subjects (69%) were Caucasian in origin. Nineteen percent of subjects were African Americans and eleven percent of subjects were Hispanics. Men had higher baseline weight (lbs) than women (324 ± 61 vs. 262 ± 45, p:< 0.001). Weight (lbs) loss at 12 month was higher in men compared to women (113 ± 37 vs. 85 ± 31). However, after adjusting for baseline weight, there was no gender difference in weight loss. Baseline weight among different ethnic groups was not different (p=0.16). Weight loss was not different among different ethnic groups (p=0.56) and was in proportion to baseline weight. Average weight loss was 33% of total body weight. Prevalence of MetS decreased from 85% to 33% (p=0.01). Prevalence of hypertriglyceridemia improved from 62% to 32% (p=<0.001). Prevalence of low HDL cholesterol decreased to 14.5% from 56% (p=<0.0001). Percentage of subjects with high blood pressure at baseline and during follow up was 87% and 68% respectively (p=0.0002). Percentage of subjects who met criteria for glucose parameter of MetS was 58% at baseline and 16% during follow up (p=0.002). Percentage of subjects who continued to have BMI > 25kg/m2 was 84.6 %.
Gastric bypass surgery was associated with significant weight loss and improvement in MetS and its components. Weight loss with gastric bypass surgery was related to baseline weight. Gastric bypass surgery was equally effective for weight loss in both men and women and in ethnic minorities.
Nothing to Disclose: PP, SA, GG, OE, NA, MC
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