Session: SUN 459-496-Thyroid Neoplasia & Case Reports
Poster Board SUN-487
Materials and methods: Clinical data of 206 patients which had undergone parathyroidectomy for PHPT were analyzed to detect the patients with coexistent DTC.
Results: DTC was found in 23 (11.2 %) patients (18 females, mean age:55,83±12,07 years). Of those patients, 22 had papillary and one minimally invasive follicular carcinoma (MIFC). The mean values of serum calcium, phosphorus and parathormone (PTH) were 11.2±1.2 mg/dl, 2.7±0.5 mg/dl and 199.4±126.9 pg/ml respectively. The parathyroid pathology of the papillary thyroid cancer (PTC) patients were adenoma (n=19) and hyperplasia (n=3). The patient with MIFC had parathyroid adenoma. There were no significant differences in calcium and PTH levels among the patients with and without DTC.
Conclusion: External radiation to head and neck region has been shown to be a common mechanism of thyroid and parathyroid tumors. The underlying pathogenetic mechanism of the coexistence of PHPT and thyroid cancer is not clear. However, high calcium levels may have oncogenic effects on thyroid gland. Insulin like growth factor and epithelial growth factor have been also shown to be involved in this carcinogenesis.
Disclosure: AC: Consultant, Novartis Pharmaceuticals, Speaker, Novartis Pharmaceuticals, Speaker, Sanofi, Consultant, Sanofi, Speaker, Astra Zeneca, Speaker, Bristol-Myers Squibb, Speaker, Novo Nordisk, Consultant, Novo Nordisk, Speaker, Eli Lilly & Company. Nothing to Disclose: MY, AG, TD, UAT, AS, TC, OO, FB
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