Session: SUN 554-573-Ovarian & Uterine Function I
Poster Board SUN-563
It is known that there are relationship between non-thyroidal illness syndrome (NTIS) and chronic illnesses such as rheumatoid arthritis, systemic lupus erythematosus, however, to date, no systematic analysis of NTIS in women with polycystic ovary syndrome (PCOS) has been undertaken. The aim of this study was to determine the existence of NTIS in patients with PCOS.
Material and Method
52 patients with PCOS were recruited for this cross-sectional study. The control group included 68 age-matched female volunteers. PCOS was defined according to the revised 2003 Rotterdam criteria. Serum free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH) (fourth generation TSH kits), anti-thyroperoxidase antibody (anti-TPO Ab), and anti-thyroglobulin antibody (anti-Tg Ab) were measured.
NTIS was not observed in either group. The TSH level in the PCOS patients and controls did not differ significantly (1.9 ± 1.2 µIU/mL vs. 1.8 ± 0.9 µIU/mL, p > 0.05). Serum fT3 and fT4 levels in the controls were significantly lower than those in the PCOS patients (fT3: 2.7 ± 0.3 pg/mL vs. 2.9 ± 0.3 pg/mL, p=0.02; fT4: 1.0 ± 0.1 ng/dL vs. 1.1 ± 0.1 ng/dL, p=0.03). The Hs-CRP level in the PCOS patients was significantly higher than that in the controls (3.5 ±4.9 mg/L vs. 1.7± 2.7 mg/L, p=0.03). A statistically significant relationship was observed between Hs-CRP and fT4 (r = 0.245, p=0.015).
Abnormal thyroid function can be observed in some chronic inflammatory diseases, but NTIS was not noted in any of the PCOS patients in the present study. So when PCOS patients are evaluated, any thyroid function test abnormalities should not attributed to non-thyroidal illness syndrome in PCOS patients and should be evaluated carefully.
Nothing to Disclose: MK, OT, MS, ZG, MS, EC, TD
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