Any Thyroid Function Test Abnormalities in Polycystic Ovary Syndrome Should not Attributed to Non-Thyroidal Illness Syndrome

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 554-573-Ovarian & Uterine Function I
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-563
Melia Karakose1, Oya Topaloglu1, Muyesser Sayki Arslan1, Zeynep Ginis1, Mustafa Sahin2, Erman Cakal*1 and Tuncay Delibasi1
1Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, 2Ankara University Faculty of Medicine, Ankara, Turkey

It is known that there are relationship between non-thyroidal illness syndrome (NTIS) and chronic illnesses such as rheumatoid arthritis, systemic lupus erythematosus, however, to date, no systematic analysis of NTIS in women with polycystic ovary syndrome (PCOS) has been undertaken. The aim of this study was to determine the existence of NTIS in patients with PCOS.


Material and Method

52 patients with PCOS were recruited for this cross-sectional study. The control group included 68 age-matched female volunteers. PCOS was defined according to the revised 2003 Rotterdam criteria. Serum free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH) (fourth generation TSH kits), anti-thyroperoxidase antibody (anti-TPO Ab), and anti-thyroglobulin antibody (anti-Tg Ab) were measured.



NTIS was not observed in either group. The TSH level in the PCOS patients and controls did not differ significantly (1.9 ± 1.2 µIU/mL vs. 1.8 ± 0.9 µIU/mL, p > 0.05). Serum fT3 and fT4 levels in the controls were significantly lower than those in the PCOS patients (fT3: 2.7 ± 0.3 pg/mL vs. 2.9 ± 0.3 pg/mL, p=0.02; fT4: 1.0 ± 0.1 ng/dL vs. 1.1 ± 0.1 ng/dL, p=0.03). The Hs-CRP level in the PCOS patients was significantly higher than that in the controls (3.5 ±4.9 mg/L vs. 1.7± 2.7 mg/L, p=0.03). A statistically significant relationship was observed between Hs-CRP and fT4 (r = 0.245, p=0.015). 



Abnormal thyroid function can be observed in some chronic inflammatory diseases, but NTIS was not noted in any of the PCOS patients in the present study. So when PCOS patients are evaluated, any thyroid function test abnormalities should not attributed to non-thyroidal illness syndrome in PCOS patients and should be evaluated carefully.

Nothing to Disclose: MK, OT, MS, ZG, MS, EC, TD

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