Session: SUN 234-256-Bone & Calcium Metabolism: Clinical Trials & Case Series
Poster Board SUN-240
To investigate this issue in the early fall of 2010 we performed a survey in a small southern Italian village. All adult residents (n=1811) were invited and 1056 accepted to participate. Blood samples were collected for measurement of serum calcium, albumin, creatinine, PTH, and 25OHD. Daily calcium intake was also evaluated using a self-administered questionnaire.
A complete set of results was available in 679 subjects (age 18-89 yr; 422 F and 257 M). Four women (0.6%) had classical PHPT. Two-hundred eighty-eight individuals (42.4%) had high plasma PTH (nl: 10-65 pg/ml) and normal albumin-adjusted serum calcium (alb-Ca; nl: 8.6-10.2 mg/dl). Two-hundred sixty-three of them were excluded because of serum 25OHD <30 ng/ml (n=241, 83.7%) or eGFR <60 ml/min/1.73 m2 (n=22, 7.6%). NPHPT was diagnosed in the remaining 25 subjects [11 F (mean age 47 yr, 5 postmenopausal) and 14 M (mean age 47 yr), with an overall prevalence of 25/679 (3.5%). PTH, alb-Ca and 25OHD (mean ±SD) concentrations were 89.0±21.5 pg/ml, 9.0±0.3 mg/dl, and 37.6±7.2 ng/ml, respectively. No relationship was found between plasma PTH and quartile of daily calcium intake.
In conclusion, in the present survey the association of high plasma PTH and normal alb-Ca is rather a common finding, and, in the majority of cases, is linked to low 25OHD levels and, less frequently, to renal failure. However, a definite proportion of subjects (3.5%) met the criteria of NPHPT. Longitudinal studies in the latter subjects are needed to establish whether NPHPT represents an early stage of classical PHPT or a separate entity.
Nothing to Disclose: CM, EV, AM, RC, FC, SC, FS
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