THE CORRELATION BETWEEN ESTROGEN RECEPTOR GENE POLYMORPHISMS AND FSH AND ESTRADIOL SERUM LEVEL WITH HUMAN

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 561-585-Ovarian & Uterine Function II
Basic/Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-575
Clarissa Mattos1, Camila Trevisan1, Carla Peluso1, Viviane Cavalcanti1, Emerson Cordts1, Denise Christofolini1, Caio Parente Barbosa1 and Bianca Bianco*2
1Faculdade de Medicina do ABC, Santo Andre, Brazil, 2Faculdade de Medicina do ABC, Sao Paulo, Brazil
INTRODUTION: Estrogen has an important role in folliculogenes and act in synergism with follicle stimulating hormone (FSH) to increase the number of FSH receptors in the granulosa cells. Some studies associated ER gene polymorphisms with response to controlled ovarian hyperstimulation and clinical pregnancy with conflict results. OBJECTIVES: To correlate FSH serum level to controlled ovarian hyperstimulation response and the influence of ERα (PvuII) and ERβ (AluI) polymorphisms in the assisted reproductive outcomes. MATERIALS AND METHODS: Study comprising 142 Brazilian infertile women that underwent in vitro fertilization: n=36 Idiopathic infertility, n=41 tube peritoneal, and n=65 male factor. All patients were younger than 38 years old, had normal prolactin and TSH serum levels, presence of both ovaries without morphological abnormalities, ovulatory cycle, body mass index ≤30, no previous history of poor ovulatory response, and no evidence of endocrine disorders or endometriosis. Detection of ER variants was performed using TaqMan methodology by real time PCR. The dosage of FSH and estradiol serum levels was made by Elisa. The results were statistically analyzed. RESULTS: Statistical analyses revealed that lower serum levels of FSH (3,67–5,89 mUI/mL) were associated to ovarian hyperstimulation syndrome (p=0,037). No difference was observed between ER gene polymorphisms and estradiol levels, controlled ovarian hyperstimulation response, number of retrieved oocytes, embryo transferred, good embryos quality and/or pregnancy rate. CONCLUSION: The results showed a positive association between lower FSH serum levels and ovarian hyperstimulation syndrome.

Nothing to Disclose: CM, CT, CP, VC, EC, DC, CPB, BB

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: CNPq/PIBIC