Isolated Vitamin D deficiency is not associated with non-thyroidal illness syndrome but with thyroid autoimmunity

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 238-262-Vitamin D Action, Deficiency & Disorders
Bench to Bedside
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-250
Muyesser Sayki Arslan1, Oya Topaloglu1, Bekir Ucan1, Melia Karakose1, Esra Tutal1, Basak Karbek1, Zeynep Ginis1, Erman Cakal*1, Mustafa Sahin2 and Tuncay Delibasi1
1Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, 2Ankara University, School of Medicine, Ankara, Turkey
Aims: Vitamin D deficiency is identified as a risk factor in the development of several autoimmune diseases. Our aims were to compare thyroid function tests, thyroid autoantibodies, and the existence of non-thyroidal illness according to vitamin D level .

Materials and Methods: Age and body mass index matched subjects included healthy volunteers with vitamin D deficiency or not. Participants were classified according to 25(OH)D level, as following; severe deficiency, <10 ng/ml, moderate deficiency, 10-20 ng/ml, and normal, ≥20ng/ml . Serum free thyroxine, triiodothyronine, thyroid stimulating hormone (TSH), anti thyroid autoantibodies, insulin resistance were determined. Whether existence of non-thyroidal illness (NTIS) or not were evaluated.

Results: We found significantly higher anti-TPO positivity in severe and moderate vitamin D deficiency groups compared to normal. Furthermore TSH levels were significantly lower in severe and moderate vitamin D deficiency groups compared to normal. There were only significant weak reverse correlation found between TPOAb positivity. There were positive correlation between TSH levels and serum 25(OH)D values. We only found one thyroid function test result compatible to NTIS in the group of moderate vitamin D deficiency; therefore the difference is not statistically significant.

Conclusions: The prevalence of thyroid autoantibody is higher in cases of lower 25(OH)D levels in healthy subjects. Further studies must be needed to determine whether vitamin D deficiency is a causal reason in the pathogenesis of the Hashimoto thyroiditis and NTIS or rather a result of the disease.

Nothing to Disclose: MS, OT, BU, MK, ET, BK, ZG, EC, MS, TD

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm