Session: MON 561-585-Ovarian & Uterine Function II
Poster Board MON-576
Objective: The aim of this study is to correlate serum and follicular levels of estradiol and homocysteine in infertile women with results of assisted reproduction.
Patients and methods: The studied groups comprised 29 women with idiopathic infertility (GI) and 44 patients with endometriosis (GII). A control group (GIII) was composed by 35 fertile women whose partner presents male infertility. All women underwent ART at Faculdade de Medicina do ABC, Brazil. The analysis of serum and follicular fluid was performed by measuring the concentrations of estradiol and homocysteine. Statistical analyses was done by Person’s correlation and considered significant when p<0.005.
Results: In GI group the serum and follicular estradiol levels were positively correlated with the number of follicles observed by US (p=0.0001; p=0.0011), oocytes retrieved (p=0.0001; p=0.0006), oocyte maturation (p=0.0006; p=0.0013), fertilization rates (p=0.0212; 0.0267) and number of embryos for transfer (p=0.0036; p=0.0078). For GII group the estradiol serum levels were only correlated with oocyte maturation (p=0.0331). Considering GIII we observed a positive correlation serum levels of estradiol with the number of follicles observed by US (p=0.0001), oocytes retrieved (p=0.0001) and oocyte maturation (p=0.0008). Fertilization rates and embryos for transfer were not evaluated in GIII. Regarding homocysteine levels, serum and follicular, we did not observe difference in the parameters evaluated.
Conclusion: We observed that higher estradiol levels, better the embryonic parameters. Except for endometriosis, an estrogens dependent disease with high circulating levels of these hormones, the serum levels of estradiol are sufficient to determine this correlation.
Nothing to Disclose: AAS, BB, JC, FAM, DC, CPB
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
See more of: Abstracts - Orals, Featured Poster Presentations, and Posters