Session: SAT 498-531-Female Repro Endocrinology & Case Reports
Poster Board SAT-516
Thyroid dysfunction (TD) is a common endocrine disorder affecting women of reproductive age associated with multiple adverse outcomes. However, the role of universal thyroid testing in pregnancy is not well stablished.
To estimate the prevalence of TD in early pregnancy in an iodine-sufficient population in Spain.
MATERIAL AND METHODS:
A prospective population-based study was conducted from April 2010 through March 2011 in a population of Northern Spain (Oviedo). All pregnant women were tested during their first gestational visit following a universal screening protocol. Antithyroperoxidase antibody (TPOAb) were checked in patients with TD. Serum TSH, FT4 and TPOAb were measured by electrochemiluminescence immunoassay (Roche Elecsys). All samples were processed in the same laboratory. Trimester-specific reference ranges for TSH and FT4 were previously defined in a group of healthy pregnant women, TPOAb negative and with an adequate iodine intake status.
We analyzed TSH and FT4 in 2517 consecutive pregnant women in their first trimester of pregnancy (median gestation 8 wk, range 4-13 wk).
417 patients were positively screened for TD (16.6%, 95% CI 15-18), mean age of 32 yr. Of these, 47 women had overt hypothyroidism (Prevalence Rate (PR) 1.9%), 90 subclinical hypothyroidism (PR 3.6%), 24 overt hyperthyroidism (1%), 20 subclinical hyperthyroidism (PR 0.8%) and 236 isolated hypothyroxinemia (PR 9.4%).
We did not find any significant association between older age (>30 yr) and risk of TD.
The prevalence of TD in pregnancy in our iodine-sufficient population is high (16.6%).
A universal screening strategy early identifies pregnant women affected with TD.
Nothing to Disclose: MD, MR, ED, JA, JP, CS, AL, AR, EM
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