PREVALENCE OF THYROID DYSFUNCTION IN PREGNANCY IN AN IODINE-SUFFICIENT POPULATION

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 498-531-Female Repro Endocrinology & Case Reports
Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-516
Marta Diéguez Felechosa1, María Riestra Fernandez*1, Elías Delgado Alvarez2, Javier Aller Granda2, Joaquin Pertierra de la Uz2, Cecilia Sánchez Ragnarsson2, Antonio Lavilla Corcobado2, Antonio Rabal Artal2 and Edelmiro Menendez Torre2
1Hospital de Cabueñes, Gijón, Spain, 2Hospital Universitario Central de Asturias, Oviedo, Spain
CONTEXT:

Thyroid dysfunction (TD) is a common endocrine disorder affecting women of reproductive age associated with multiple adverse outcomes. However, the role of universal thyroid testing in pregnancy is not well stablished.

OBJETIVE:

To estimate the prevalence of TD in early pregnancy in an iodine-sufficient population in Spain.

MATERIAL AND METHODS:

A prospective population-based study was conducted from April 2010 through March 2011 in a population of Northern Spain (Oviedo). All pregnant women were tested during their first gestational visit following a universal screening protocol. Antithyroperoxidase  antibody (TPOAb) were checked in patients with TD. Serum TSH, FT4 and TPOAb were measured by electrochemiluminescence immunoassay (Roche Elecsys). All samples were processed in the same laboratory. Trimester-specific reference ranges for TSH and FT4 were previously defined in a group of healthy pregnant women,  TPOAb negative and with an adequate iodine intake status.

RESULTS:

We analyzed TSH and FT4 in 2517 consecutive pregnant women in their first trimester of pregnancy (median gestation 8 wk, range 4-13 wk).

417 patients were positively screened for TD (16.6%, 95% CI 15-18), mean age of 32 yr. Of these, 47 women had overt hypothyroidism (Prevalence Rate (PR) 1.9%), 90 subclinical hypothyroidism (PR 3.6%), 24 overt hyperthyroidism (1%), 20 subclinical hyperthyroidism (PR 0.8%) and 236  isolated hypothyroxinemia (PR 9.4%).

We did not find any significant association between older age (>30 yr) and risk of TD.

CONCLUSIONS:

The prevalence of TD in pregnancy in our iodine-sufficient population is high (16.6%).

A universal screening strategy early identifies pregnant women affected with TD.

Nothing to Disclose: MD, MR, ED, JA, JP, CS, AL, AR, EM

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm