Session: OR09-Obesity: Physiologic Responses to Energy Balance Disruption
Room 307 (Moscone Center)
Objectives: We tested the hypothesis that CT would be resistant to bodyweight gain.
Design:A 4-week fat overfeeding (630 kcal excess), performed in an ambulatory position, compared 8 CT women (BMI<17.5kg/m²) and 8 female controls (BMI 18.5-25kg/m²): Bodyweight, food intake, urinary metabolomics profiles, body composition, energy expenditure (EE) and appetite regulatory hormones profile after test meal were monitored before and after dietary intervention.
Results: Four weeks of fat overfeeding failed to increase bodyweight in CTs (+0.225 kg ± 0.180; controls: +0.725 kg ± 0.268, p=0.26 and 0.03 vs. baseline respectively) despite a well-documented compliance with dietary intervention: dietary records, lipid assessment, fat oxidation and metabolomics. Appetite regulatory hormones exhibited an overall anorexigenic adaptive response in CTs with significant increase in post-meal Peptide YY and Glucagon like Peptide type 1, inefficient to counteract the supervised overfeeding but may partly explain CTs eating behavior and play a role in bodyweight gain resistance. Resting EE increased in CTs only with no increase in activity energy expenditure, explaining partially the bodyweight gain resistance. Over all, CTs displayed a paradoxical positive energy balance after overfeeding contrasting with the bodyweight gain resistance. This gap in energy balance could suggest specific EE in CTs.
Conclusion:This study proposes CT as a human model of bodyweight gain resistance in a fat overfeeding paradigm.
This study is registered in Clinical Trial.gov, no. NCT01224561
Nothing to Disclose: NG, BG, DC, DG, EP, JFM, YB, JSM, SRB, JPE, ABE
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
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