Session: OR05-Lipids: Regulation & Mechanism of Disease
Room 133 (Moscone Center)
Objective:To determine the impact of the environment on lipid parameters of couples in the Framingham Heart Study.
Methods: We examined the second and third generations of the FHS (n= 9,219 participants) and performed linear regression analyses comparing lipid levels of mothers and fathers from Generation 2 to their offspring from Generation 3. To compare the effect of shared environment to the effect of shared genetics, we then analyzed correlation between parents from Generation 2, who were unrelated but shared a living environment. Correlations (R2) of lipid traits were computed and adjusted for BMI, age, smoking status, and menopausal status.
Results: The relationship of parent to offspring lipid traits was highly significant, even when adjusted for confounders. The relationship of parent-to-child LDL was the most significant with R2=0.089; the comparison of father to mother (parent-parent) LDL was much lower with R2=0.010. The total variance of offspring’s HDL explained by parental HDL was 5%, while parent-to-parent comparison accounted for only 0.8% of observed variance. As expected, triglycerides were the most variable lipid with little of the variance explained either by parent of origin or shared environment (R2 0.013 and 0.003, respectively). The p-values for each comparison were highly significant (p<1e-4) aside from parent-parent TG (p=0.449).
Conclusions:There is a significant relationship between lipid phenotypes of parents and offspring, whereas the influence of environment is small but statistically significant. These results support a dominant role of genetics over environment in determining serum lipid levels.
Nothing to Disclose: JSL, IMP, WSB, MRFL, SF, SMW
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