Session: OR21-HPA Axis: New Clinical Developments
Room 134 (Moscone Center)
Methods: Here we describe three male and six female patients with presentation and clinical course consistent with a diagnosis of LH. In 5 of 9, the diagnosis of LH was subsequently confirmed by histopathological examination of resected sellar or suprasellar tissue. Clinical data including endocrine function were assessed and HLA typing performed in the 9 patients with LH and an additional 15 patients with other sellar abnormalities.
Results: Two common major histocompatibility class II human leukocyte antigen (HLA) markers, DQ8 and DRw53, were found in all 9 patients with LH (either based on clinical presentation or confirmed by histopathology). Importantly, the HLA markers were negative in the 15 control patients with other sellar abnormalities.
Conclusion: The HLA markers, DQ8 and DRw53, both associated with an increased incidence of autoimmune diseases, were found to be commonly present in patients with LH. Assessment of serum DQ8 and DRw53 HLA markers may provide a rapid way to assist in diagnosis of LH and potentially avoid unnecessary biopsy in atypical cases of LH.
Disclosure: APH: Medical Advisory Board Member, Novartis Pharmaceuticals, Medical Advisory Board Member, Ipsen. Nothing to Disclose: MB, BS, LL
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