Session: SUN 524-553-Male Reproductive Endocrinology
Bench to Bedside
Poster Board SUN-547
Our aim was to study the prevalence of different AZF deletions in men with severe oligo- and azoospermia, their hormonal status, related to the deletion discovered.
Materials and methods: 243 men with severe oligozoospermia (concentration not more than 5 mln per ml) and/or azoospermia were included in the study. All patients underwent hormonal analysis (serum FSH, Testosterone and LH levels) and genetic analyses including; AZF deletions and karyotype. All patients were divided into groups, according to AZF microdeletion found. Patients with both AZF deletions and aneuploidy were excluded. Statistical analysis was performed using Kruskal-Wallis test
Results: All men were divided into groups, according to the AZF deletion discovered. AZF deletions were found in 39 men (16%): 2 men (0.8%) - complete AZFb+c deletion (1 group), 7 (2.9%) - complete AZFc deletion (2 group), and the rest with partial deletions: 16 men (6.6%) - b2/b3 deletion (3 group), 10 men (4.1%) had gr/gr deletion (4 group), 4- AZF deletions with aneuploidy (1.6%) were excluded from the study. There was no difference found in concentration of spermatozoa [p=0.18], FSH [p=0.46], LH [p=0.7] and testosterone [p=0.73] levels between the groups.
Conclusion: No statistical difference was found in FSH, LH, testosterone levels between different study groups. The study showed b2/b3 is the most frequent partial AZF deletion. As it known b2/b3 deletion is associated with spermatogenesis impairment in Chinese men, same association was found in infertile men of Moroccan ancestry. Higher prevalence of b2/b3 deletions found can be explained by the heterogeneity of population in Russia, case-controlled studies needed to compare the distribution and impact of AZF deletions.
Nothing to Disclose: GM, YT, VZ, SZ
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