Session: SAT 622-631-Pediatric Endocrinology: Thyroid
Poster Board SAT-629
Objective: To describe ns-TSH values in Chilean neonates.
Subjects and methods: We analyzed data from 2356 neonates, born in the Pontificia Universidad Católica de Chile Hospital between July 2010 and April 2011. We did not exclude newborns presenting comorbidities or admitted to intensive care unit. ns-TSH levels were determined with the DELFIA system, and results are expressed as median, 3rd and 97thcentiles.
Results: Mean gestational age was 38.07 ± 2.1 weeks and mean birth weight was 3216.09 ± 583.4 g. The median ns-TSH was 2.97 mU/L [0.58 and 10.95 mU/L]. The percentage of neonates with ns-TSH levels >15 mU/L was 0.59 %, and 3.23% presented ns-TSH between 10 and 15 mU/L. Also, 0.33% had ns-TSH < 0.10 mU/L.
Conclusion: The 97 percentile value of this sample was lower than the cutoff of neonatal TSH currently used in Chile. Regarding these results, we recommend the follow up newborns with ns-TSH between 10 and 15 mIU/L and to evaluate costs and benefits of lowering the cut-off from 15 to 10 mIU/L. Newborns with TSH < 0.58 mIU/L should be evaluated.
Nothing to Disclose: FG, ML, HP, LV, DIC, AM
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