Session: MON 796-817-Diabetes Genetics & Epidemiology
Poster Board MON-806
Methods. This was a case-control association study comprising 995 T2DM patients and 1,195 normoglycaemic control participants. We genotyped by allelic discrimination method 18 SNPs in or near ADAM30, NOTCH2, THADA, TMEFF2, COL8A1, ADAMTS9-AS2, WFS1, JAZF1, SLC30A8, KCNQ1, LOC387761, ALX4, TSPAN8, FTO, and HNF1, which were previously associated with T2DM in European populations.
Results. The risk-allele frequencies of the tested SNPs were comparable with those reported for Caucasians. We demonstrated significant associations of COL8A1 rs792837 [P <0.001; OR(95% CI) = 1.45 (1.24-1.68)], KCNQ1 rs2237892 [P <0.001; OR(95% CI) = 2.53 (2.09-3.05)] and rs2237895 [P = 0.014; OR(95% CI) = 1.20 (1.04-1.38)], ALX4 rs729287 [P = 0.001; OR(95% CI) = 1.36 (1.13-1.65)], FTO rs8050136 [P = 0.039; OR(95% CI) = 1.16 (1.01-1.34)] and rs17817449 [P = 0.036; OR(95% CI) = 1.18 (1.01-1.37)], and HNF1 rs4430796 [P = 0.008; OR(95% CI) = 0.80 (0.68-1.95)] with T2DM, with similar effect sizes to those reported for European populations. Lack of association for the rest of the variants may have resulted from insufficient power to detect smaller allele effects.
Conclusions/interpretation. In addition to our previous findings demonstrating the association of IGF2BP2, CDKAL1, TCF7L2 and EXT2 variants with T2DM among Lebanese, here we extend these by validating the association of six additional established loci with T2DM in Lebanese Arabs.
Nothing to Disclose: WYA, RFN, ASE, FLS, SHK
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