Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Poster Board SUN-273
Subjects and Methods: Ninety-two female subjects, 45 premenopausal (42 ± 7yo) and 47 post menopausal women (60 ± 5 yo) were enrolled. Intact parathyroid hormone (iPTH) and Ca levels were determined by our biochemical laboratory. 25OHD levels and DBP levels were determined by radioimmunoassay and an ELISA, respectively.
Results: There are no significant difference in calcium (9.4 ± 0.6 vs 9.5 ± 0.9mg/dl), BMI (29 ± 4 vs 31 ± 5 kg/ m2), 25OHD (26.6 ± 8.7 vs 25.3 ± 6.3 ng/ ml) and iPTH levels (41.8 ± 19.9 vs 39.7 ± 17.6 pg/ml) between pre- and post-menopausal women (P>0.05). DBP levels were lower in postmenopausal (41.2±16.1 mg/dl) compared to premenopausal women (50.42±22.0 mg/dl, P < 0.01). DBP levels were inversely correlated with age in these female subjects (r = -0.35, p < 0.05).
Conclusions: DBP levels were lower in postmenopausal women and levels were inversely correlated with age. It is possible that higher circulating estradiol concentrations up-regulates liver DBP production and are influencing these results, but factors related to aging may have an independent effect. The physiological significance of lower DBP levels in postmenopausal women requires further investigation.
Nothing to Disclose: XW, SAS
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