APOLIPOPROTEIN B AS AN INDEPENDENT PREDICTOR OF VASCULAR STIFFNESS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 776-795-Cardiometabolic Risk & Vascular Biology
Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-792
Rattana Leelawattana*
Prince of Songkla University, Songkla, Thailand
Apolipoprotein B as an independent predictor of vascular stiffness in Systemic Lupus Erythematosus patients

Jirateep  Kwankaew1, Rattana Leelawattana1, Anchalee Saignam2

1Division of Endocrinology and Metabolism, 2Division of Rheumatology, Department of Medicine, Faculty of Medicine, Songklanagarind hospital,

Prince of Songkla university, Songkhla, Thailand

Corresponding author

Rattana Leelawattana, MD

Division of Endocrinology and Metabolism

Department of Medicine

Songklanagarind Hospital, Prince of Songkla University,

Songkhla, Thailand 10400

Email: Lrattana@medicine.psu.ac.th


Abstract

Objective: Patients with systemic lupus erythematosus (SLE) often suffer from systemic inflammation and have higher risk of atherosclerosis which could be detected early by their vascular stiffness. Our objective was to study the relationship in Apo-B levels and vascular stiffness determined by brachial-ankle pulse wave velocity (baPWV) in patients with systemic lupus erythematosus (SLE)

Methods: Eighty-seven Thai SLE subjects were studied. Fasting blood was collected for creatinine, glucose, lipid profiles including Apo-B and Apo-A1. BaPWV was measured by non-invasive vascular screening device. Pearson correlation and stepwise-linear regression were used for the analysis.

Results: The average age of subjects was 36.69+10.85 years. Mean value for baPWV was 1,332+274.12 cm/s. Thirty six percent of patients were classified into increased vascular stiffness group as defined by baPWV greater than 1,400 cm/s. Mean Apo-B level in normal vascular stiffness and increased vascular stiffness group were 94.32 + 24.81 and 105.02 + 31.45 mg/dl. There were correlation of baPWV and age, systolic BP, diastolic BP and creatinine clearance. Apo-B tended to associate with baPWV (p=0.06) whereas LDL-C did not (p=0.2). By multiple regression analysis, systolic BP, age and Apo-B were the significant predictors of baPWV.

Conclusions: Apo-B level associated with vascular stiffness independent of other factors in Thai SLE subjects.

Keywords: SLE, atherosclerosis, brachial-ankle pulse wave velocity, lipid profiles, apolipoprotein-B levels

Nothing to Disclose: RL

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: Research Grant; Faculty of Medicine, Prince of Songkla University