Session: SUN 807-838-Diabetes - Diagnosis, Complications & Outcomes
Poster Board SUN-829
Type -1 diabetes mellitus (TIDM) causes endothelial dysfunction and early atherosclerosis, which is a risk factor for premature coronary artery disease (1,2).
OBJECTIVES. To determine the impact of different levels of glycemic control and vascular oxidative stress/inflammation on vascular health in adolescents with T1DM.
METHODS. Cross sectional study in adolescents >12 years 2 years post diagnosis of TIDM who were divided into 2 groups, Group 1 - A1c≤ 8.5% and Group 2 - A1c≥ 9.5%. The sample size was 52, 27 in group 1 and 25 in group 2. The subjects underwent measurement of Carotid artery intima media thickness (cIMT) and peripheral tonometry measurement (PAT)). Bio-markers of inflammation measured included CRP, IL-6, sICAM-1, sE-selectin, fibrinogen and TNF-α.
RESULTS: Plasma sE-selectin level was significantly different in the 2 groups with higher levels in group 2 (48.8±21.5 vs. 65.0±27.7, p: 0.02). c-IMT and PAT were not significantly different between the 2 groups. Other markers of inflammation, CRP, IL-6, sICAM-1, fibrinogen and TNF-α were also not significantly different between the 2 groups. Pearson correlation showed that there was a significant direct relationship between rising A1c values and mean right cIMT (p=0.02; r= 0.37), PAT (p=0.03, r=0.31) and fibrinogen (p= 0.03, r=0.03).
Nothing to Disclose: GSB, MAC, DD, GR
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