Oxidative stress, endothelial dysfunction, carotid artery intima-media thickness and biomarkers of vascular inflammation in adolescents with Type-1 diabetes mellitus

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 807-838-Diabetes - Diagnosis, Complications & Outcomes
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-829
Ghufran S Babar*1, Mark A Clements2, Daisy Dai3 and Geetha Raghuveer3
1Children's Mercy Hosp & Clinic, Kansas City, MO, 2Children's Mercy Hospital, Kansas City, MO, 3CHILDRENS MERCY HOSPITAL AND CLINICS, KANSAS CITY, MO

Type -1 diabetes mellitus (TIDM) causes endothelial dysfunction and early atherosclerosis, which is a risk factor for premature coronary artery disease (1,2).

OBJECTIVES. To determine the impact of different levels of glycemic control and vascular oxidative stress/inflammation on vascular health in adolescents with T1DM.

METHODS. Cross sectional study in adolescents >12 years 2 years post diagnosis of TIDM who were divided into 2 groups, Group 1 - A1c≤ 8.5% and Group 2 - A1c≥ 9.5%. The sample size was 52, 27 in group 1 and 25 in group 2. The subjects underwent measurement of Carotid artery intima media thickness (cIMT) and peripheral tonometry measurement (PAT)). Bio-markers of inflammation measured included CRP, IL-6, sICAM-1, sE-selectin, fibrinogen and TNF-α.

RESULTS: Plasma sE-selectin level was significantly different in the 2 groups with higher levels in group 2 (48.8±21.5 vs. 65.0±27.7, p: 0.02). c-IMT and PAT were not significantly different between the 2 groups. Other markers of inflammation, CRP, IL-6, sICAM-1, fibrinogen and TNF-α were also not significantly different between the 2 groups. Pearson correlation showed that there was a significant direct relationship between rising A1c values and mean right cIMT (p=0.02; r= 0.37), PAT (p=0.03, r=0.31) and fibrinogen (p= 0.03, r=0.03).

1. Larsen J, Brekke M, Sandvik L, Arnesen H, Hanssen KF, Dahl-Jorgensen K (2002) Silent coronary atheromatosis in type 1 diabetic patients and its relation to long-term glycemic control. Diabetes 51:2637–2641. 17. 2. Singh TP, Groehn H, Kazmers A. Vascular function and carotid intimal-medial thickness in children with insulin-dependent diabetes mellitus. J Am Coll Cardiol. 2003; 41: 661–665.

Nothing to Disclose: GSB, MAC, DD, GR

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: Local Katherine B. Richardson Grant.