Session: SAT 554-583-Male Reproductive Endocrinology & Case Reports
Poster Board SAT-574
Objective: To determine whether CC therapy was effective in increasing serum T levels in HG post-pubertal obese males <21 year.
Materials and Method: A retrospective cohort study using data from medical and laboratory records of obese men aged 18-21 yr. Those found to be HG (early morning T level <350 ng/dl) were given 25mg CC on alternate days. Out of 20 HG patients, 12 were analyzed. Baseline serum T, LH and FSH were compared with post-treatment levels at 3 months. Also weight and BMI z-score were compared at baseline and after 3 months of CC treatment.
Results: Baseline T levels were 233±66 ng/dl and increased to 581 ± 161 ng/dl (p < 0.0001) after 3 month of CC treatment. Baseline LH levels increased from 3.3 ±1.6 mIU/mL to 5.7 ± 1.7 mIU/mL (p=0.027). Similarly, baseline FSH levels increased from 2.8 ± 1.5 mIU/mL to 6.2 ± 3 mIU/mL after CC treatment (p=0.026). There was no correlation between weight or BMI z-score and the baseline or post treatment T, LH, or FSH levels.
Conclusion: This is the first study looking at CC therapy in obese post-pubertal HG men <21 year. The anti-estrogen CC effectively increases T in obese post-pubertal HG men, similar to efficacy of CC in adult men older than 21 years. We feel that CC should be incorporated as an initial therapy for obesity in HG young adults. Future, prospective larger studies need to be done to address this question.
Nothing to Disclose: MCV, SB
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
See more of: Abstracts - Orals, Featured Poster Presentations, and Posters