Session: SAT 786-805-Diabetes & Obesity Therapeutics
Bench to Bedside
Poster Board SAT-791
OBJECTIVE: To compare patients with DM1 in use of human insulin and insulin analogs as the mean blood glucose levels, HbA1c, risk of hypoglycemia (via LBGI-Low Blood Glucose Index) and hyperglycemia (via HBGI-Hight Blood Glucose Index) and variability glucose (via SD).
PATIENTS AND METHODS: We evaluated 24 patients with type 1 diabetes between 2010 and 2011, instructed to perform six measures of blood glucose daily for a period of three weeks. The mean blood glucose values, SD,LBGI and HBGI were calculated by the data manager Accu-Chek® 360º Roche. Personal and HbA1C were collected from medical records. We used the Mann-Whitney test to compare the data.
RESULTS: The patients were divided into two groups: basal insulin NPH (n = 9, mean age: 29.78 years) x basal insulin analogs (n = 15 - Detemir: 2 and Glargine: 13, mean age: 33.27 years).
DISCUSSION: The NPH group achieved a mean HbA1c and mean blood glucose greater than the Analogs group, but without statistical significance, which may mean that obtaining these parameters independent of insulin regimen chosen. Moreover the values of SD indicate favorably to the group Analogs to indicate a lower glycemic variability. The most recent data show that glycemic variability may imply a significant risk of complications. A comparison of HBGI showed increased risk of hyperglycemia group using NPH. The LBGI was lower in Analogs, but are not able to show superiority of any treatment on the risk of hypoglycemia.
CONCLUSION: The data analysis suggests that patients with DM1 treated with basal insulin analogs may have a reduced glycemic variability and therefore less risk of macrovascular and microvascular chronic complications compared with those on basal insulin NPH.
Nothing to Disclose: FGM, JES, NMS, DFNS, EPGV
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
See more of: Abstracts - Orals, Featured Poster Presentations, and Posters