S39-3 e-Trials and Community-Based Research

Program: Symposia
Session: S39-Reducing Health Disparities Through Clinical Trials
Clinical
Sunday, June 16, 2013: 4:00 PM-5:30 PM
Presentation Start Time: 5:00 PM
Room 104 (Moscone Center)
Erwin P Bottinger*
Icahn School of Medicine at Mount Sinai, New York, NY
Talk Description:

The Mount Sinai Medical Center of New York City provides healthcare at the intersection of diverse communities of Northern Manhattan such as Harlem, East Harlem, upper East side and upper West side. Among these communities, health disparities in common complex conditions are of considerable concern. We have implemented a new approach to establish a clinical care cohort of individuals from local communities receiving care at Mount Sinai. Participants consent to open future biomedical research using their electronic health records and biosamples, including DNA and plasma. To date, over 25,000 participants enrolled, of which 15,000 have been genotyped for common and rare DNA variants using state-of-the-art genomic methods. Clinically-relevant phenotype data is extracted from electronic health records by customized electronic phenotyping algorithms encoded as executable software. A multi-disciplinary team including expert clinicians, informaticians, health services experts, population geneticists and genetic epidemiologists are pursuing numerous research projects using this unique real-life clinical care cohort of individuals from diverse communities of Northern Manhattan. This talk will describe rationale, design, implementation, opportunities and challenges, and ongoing studies of the Mount Sinai BioMe clinical care cohort.

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