Kristy A Brown, PhD

Prince Henry's Institute
Metabolism and Cancer

Biographical Sketch:
Dr Brown is an NHMRC (Australia) Career Development Fellow and Co-Head of the Metabolism & Cancer laboratory at Prince Henry’s Institute, and an adjunct lecturer in the Department of Physiology at Monash University. Dr Brown has over 10 years experience in sex hormone biology, specialising in the study of the regulation of enzymes involved in the biosynthesis of sex hormones. Her research interests are aimed at elucidating the mechanisms whereby dysregulated metabolism leads to the increased risk of breast cancer. Her recent work identified the LKB1/AMPK pathway, central regulator of energy homeostasis, as a modulator of oestrogen production within the breast, thereby providing a molecular link between obesity and breast cancer. Dr. Brown’s current research interests include understanding metabolic signalling pathways which regulate oestrogen production in the breast adipose in the context of obesity and cancer, and to investigate potential therapeutics that target these pathways in the clinical setting.
Papers:
Early Career Forum
Opportunities for International Early Career Professionals
Nuclear p53 is decreased in the tumour-associated stroma: regulation by prostaglandin E2 and implications for aromatase regulation
CDW04 Opportunities for International Early Career Professionals
FP11-6 Estrogen Excess Phenotype Associated With Loss of Heterozygosity of the STK11 Gene in the Testis of Two Boys With Peutz Jeghers Syndrome