Jamie T Bridgham, PhD

Research Associate
University of Oregon
Institute of Ecology and Evolutionary Biology

Biographical Sketch:
Jamie Bridgham is currently a research associate at the University of Oregon. She has an extensive background using molecular biology tools to answer questions across a wide range of biological topics including reproductive physiology, biochemistry and evolutionary biology. She received her master’s degree in Ecology and Evolution from the University of Minnesota, and her PhD working with Alan Johnson at the University of Notre Dame. She has been a laboratory manager for over 20 years. Her previous research interests involved several different model systems and questions, including Drosophila population genetics, yeast iron uptake and avian reproductive physiology. Her dissertation focused on the molecular biology and physiology of cell death signaling pathways in ovarian granulosa cells. That project concluded with a paper describing the evolution of tumor necrosis factor receptor family members. She was awarded an NIH postdoctoral fellowship to expand her training in evolutionary biology with Joe Thornton at the University of Oregon, where she studied the evolution of steroid receptors. Jamie currently holds a long-term position as a research associate and lab manager with the Thornton lab. They use a powerful approach integrating phylogenetics, ancestral protein reconstruction, and assays of molecular function, protein biochemistry, and biophysics to understand how steroid receptors have evolved to recognize different molecular partners, both hormonal ligands and specific DNA response elements.
Papers:
S13 Evolution of Nuclear Receptors
S13-1 Diversity in Nuclear Receptors: Evolution of Hormone Sensitivity from a Constitutive ERR