Daniel D Bikle, MD, PhD

VA Med Ctr
111N-UCSF Medicine

Biographical Sketch:
Dr.Bikle is Professor of Medicine and Dermatology at the University of California San Francisco and Staff Endocrinologist at the SFVA Medical Center. His MD and PhD training occurred between Harvard and the University of Pennsylvania. He is a member of a number of organizations including the Endocrine Society, American Society for Bone and Mineral Research, Society for Investigative Dermatology and Association of American Physicians. He has a long standing interest in vitamin D, both clinical and basic, with current research focusing on the molecular mechanisms of action of the vitamin D receptor. He also has a strong research interest in the hormonal regulation of bone development and remodeling, focusing on the roles of IGF1 and PTH. Clinically, Dr. Bikle has special interests in hormonal disorders of bone mineral metabolism including vitamin D deficiency. He is the author of over 300 manuscripts including textbook chapters and reviews in these areas.
Papers:
Vitamin D Deficiency:Metabolic Consequences
Skeletal IGF-1 Signaling Impacts Glucose and Energy Metabolism
IGF-1 and Integrin signaling pathways cooperatively modulate the response of osteoblastic cells to IGF-1 and shear stress
FP31 Disorders of Vitamin D Metabolism & Action
FP24-1 IGF-I Signaling Regulates Endochondral Bone Formation Via EphrinB2/EphB4 Mediated Vascularization
M52 Vitamin D Deficiency:Metabolic Consequences
OR01-5 Osteoblast-specific Knockout of the Insulin-like Growth Factor I Receptor (IGF-IR) Gene Impairs Endochondral Bone Formation in Unstable Fracture Healing
OR31 Disorders of Vitamin D Metabolism & Action