University of Würzburg
Pharmacology and Toxicology / Rudolf Virchow Center
Biographical Sketch: Martin Lohse studied medicine and philosophy in Göttingen, London and Paris. He did his doctoral thesis in neurobiology at the Max-Planck-Institute for Biophysical Chemistry. He was a post-doc with Ulrich Schwabe at the University of Heidelberg and then joined the group of Robert Lefkowitz at Duke University as an assistant professor. From 1990 to 1993 he was a group leader at the GeneCenter Munich/ Martinsried, and in 1993 he moved to his current position as Chairman of the Institute of Pharmacology and Toxicology at the University of Würzburg. In 2001 he also became the Founding Chairman of the Rudolf-Virchow-Center/DFG-Research Center for Experimental Biomedicine. Since 2009 he is also Vice President for Research of the University of Würzburg, and Vice President of the National Academy of Sciences Leopoldina.
His research interests concern the mechanisms and physiological functions of G protein-coupled receptors (GPCRs). He has discovered the beta-arrestins as regulators of GPCRs and their signals, and the regulatory roles of phosducins on G protein-mediated signals. More recently, his laboratory has invented fluoresecence techniques to image GPCR activation and signaling in living cells with high temporal and spatial resolution. Other topics of his research are the role of GPCRs and their signaling pathways in cardiac myocytes, and their alterations in heart hypertrophy and failure, as well as GPCR signaling in neurons and in endocrine cells.
Monitoring GPCR Activation and Signaling by Real Time Fluorescence Microscopy